Holoxan
Holoxan is a cancer medicine that stops cancer cells from growing and dividing.
Form
injektio-/infuusiokuiva-aine liuosta varten
Strength
1000 mg
Active Ingredient
Ifosfamide
Manufacturer
Baxter Oy
How to Use
Dosage
Your doctor will decide your dose based on your illness and condition.
Method
The medicine is given as a slow drip into a vein by hospital staff.
Important
Your doctor will ensure you receive the correct amount of medicine.
Possible Side Effects
COMMON
- •Reduced bone marrow function (fewer white blood cells, platelets, and red blood cells).
- •Nausea and vomiting.
- •Hair loss.
- •Brain function problems (e.g., confusion).
- •Bladder inflammation (blood in urine).
- •Fever.
- •Infections.
- •Too much acid in the body.
- •Poor appetite.
- •Vein inflammation.
- •Liver problems.
- •Fewer sperm cells.
- •Fatigue and feeling unwell.
RARE
- •Severe blood poisoning (sepsis).
- •New cancers (as a result of treatment).
- •Mood changes, confusion, hallucinations.
- •Dizziness.
- •Irregular heartbeats and weakened heart.
- •Low blood pressure.
- •Diarrhea and constipation.
- •Mouth inflammation.
- •High liver enzyme levels in blood tests.
- •Frequent urination, incontinence, bladder irritation.
- •Missed periods or problems with egg release.
- •Muscle cramps.
- •Severe allergic reaction (swelling of face, tongue, throat, difficulty swallowing or breathing, hives).
- •Kidney disease (poor kidney function).
- •Body swelling due to fluid buildup.
- •Imbalance of salt levels in the blood.
- •Shortness of breath, cough, lung inflammation.
- •Inability to control bowel movements.
- •Blurred or impaired vision.
- •Redness or pain at the injection site.
- •Severe blood clotting problems.
- •Serious blood disorder (hemolytic uremic syndrome).
- •Seizures (including epilepsy).
- •Heart attack, cardiac arrest.
- •Acute pancreas inflammation.
- •Severe skin reactions with peeling skin.
- •Worsening of existing cancer.
- •Blood side effects (e.g., red blood cell breakdown).
- •Weakened immune system.
- •High blood sugar.
- •Increased thirst.
- •Rapid breakdown of tumor cells.
- •Speech difficulties, twitching, walking problems, nerve damage in hands and feet.
- •Eye inflammation, eye irritation.
- •Ringing in ears, hearing loss or deafness.
- •Fluid around the heart, heart muscle disease, chest pain, heart inflammation, heart failure-like condition.
- •Pain.
- •Blood clots, blood vessel inflammation, high blood pressure.
- •Hot flashes.
- •Severe acute breathing difficulty.
- •Bowel inflammation and bleeding, stomach pain, increased saliva.
- •Blocked bile ducts.
- •Liver blood clot, liver failure, liver inflammation.
- •Severe skin and mucous membrane inflammation.
- •Worsening of skin damage after radiation therapy.
- •Skin and nail changes, small bleeding spots on the skin.
- •Increased sweating.
- •Itching.
- •Muscle and joint pain, hand and foot pain, slow growth.
- •Very large amounts of urine, feeling of incomplete bladder emptying, kidney inflammation.
- •Infertility, early menopause, poor ovarian function.
- •Slowed growth (in children).
- •Multiple organ dysfunction.
- •Chills.
Important Warnings
- Do not use if you are allergic to ifosfamide (e.g., breathing difficulties, facial swelling).
- Do not use if your bone marrow function is weak.
- Do not use if your kidneys are not working well, if your urinary tract is blocked, or if you have a bladder infection.
- Do not use if you have an infection.
- Do not use if you have cancer metastases in your brain.
Show 13 more warnings
- Do not breastfeed during Holoxan treatment.
- Contact your doctor immediately if you see blood in your urine.
- Tell your doctor right away if you feel confused, very tired, or have a severe headache.
- Discuss vaccinations with your doctor before or during Holoxan treatment.
- Tell your doctor if you have kidney, liver, bone marrow, or heart disease.
- Do not get pregnant during treatment, and do not try to have children for 6 months after treatment. Talk to your doctor.
- Holoxan can damage the bladder and cause bleeding.
- Holoxan may slow down wound healing. Keep wounds clean.
- Holoxan can damage your kidneys. Your doctor will monitor your kidney function.
- Tell your doctor immediately if you have breathing difficulties.
- Holoxan can harm your heart or cause irregular heartbeats.
- Alcohol can increase the risk of nausea and vomiting.
- Do not drive or use machines if Holoxan makes you dizzy or affects your vision.