Flumazenil Hameln
Flumazenil is used to fully or partly reverse the sedating effects of benzodiazepines, helping patients wake up after sedation or recover from an overdose.
Form
injektio-/infuusioneste, liuos
Strength
0.1 mg/ml
Active Ingredient
Flumazenil
Manufacturer
Hameln Pharma GmbH
How to Use
Dosage
The usual starting dose is 0.2 mg given into a vein over 15 seconds, and additional doses can be given if needed.
Method
This medicine is given as an injection or infusion into a vein by a doctor or nurse.
Important
For adults, the maximum dose is usually 1 mg (in anesthesia) or 2 mg (in intensive care); for children, it's up to 1 mg or 0.05 mg/kg, whichever is lower.
Possible Side Effects
COMMON
- •Nausea
- •Allergic reactions
- •Mood changes
- •Insomnia
- •Drowsiness
- •Dizziness
- •Headache
- •Trembling or shaking
- •Dry mouth
- •Fast breathing (hyperventilation)
- •Speech disorder
- •Strange skin sensations (e.g., pins and needles, cold, warmth, pressure)
- •Double vision or squinting
- •Increased tear production
- •Flushing (redness of the skin)
- •Low blood pressure when standing up
- •Temporary high blood pressure
- •Vomiting
- •Hiccups
- •Sweating
- •Pain at the injection site
- •Anxiety (after rapid injection)
- •Agitation or restlessness (after rapid injection)
- •Palpitations (fast or irregular heartbeat after rapid injection)
RARE
- •Fear
- •Convulsions or seizures
- •Abnormal hearing
- •Fast or slow heartbeat
- •Extra heartbeats
- •Shortness of breath
- •Cough
- •Stuffy nose
- •Chest pain
- •Chills
- •Severe allergic reaction (e.g., swelling of lips, face, throat, difficulty breathing)
- •Withdrawal symptoms (anxiety, confusion, hallucinations, tremors, panic attacks, aggression) in long-term benzodiazepine users
- •Unusual crying, agitation, and aggression in children
Important Warnings
- Do not use if you are allergic to flumazenil or any other ingredients in this medicine.
- Do not use if benzodiazepines were used for life-threatening conditions, such as high brain pressure or severe epileptic seizures.
- Tell your doctor if you have epilepsy and have used benzodiazepines for a long time, as flumazenil can cause seizures.
- Inform your doctor if your liver is not working well.
- Tell your doctor if you have a severe head injury or high brain pressure, as flumazenil can increase brain pressure.
Show 6 more warnings
- If you have a history of anxiety or panic attacks, flumazenil may cause new attacks.
- If you have used benzodiazepines for a long time or in high doses, a rapid flumazenil injection can cause withdrawal symptoms.
- If you are dependent on alcohol or sleeping pills, you have a higher risk of withdrawal symptoms.
- The sedating effect of the medicine might return, so you will be monitored until the effect has completely worn off.
- Do not drive or operate machinery for 24 hours after receiving this medicine.
- Do not breastfeed for 24 hours after receiving this medicine.