Everolimus Sandoz
Everolimus Sandoz is a cancer medicine that works by reducing blood flow to tumors and slowing down the growth and spread of cancer cells.
Form
tabletti
Strength
10 mg
Active Ingredient
Everolimus
Manufacturer
Sandoz A/S
How to Use
Dosage
The usual dose is 10 mg once a day. Your doctor will tell you how many tablets to take. If you have liver problems, your doctor might prescribe a lower starting dose (2.5 mg, 5 mg, or 7.5 mg daily).
Method
Take Everolimus Sandoz once a day at about the same time each day, with or without food. Swallow the tablet(s) whole with a glass of water. Do not chew or crush the tablets.
Important
The recommended maximum dose is 10 mg once daily, but your doctor may prescribe a different dose, for example, due to liver problems.
Possible Side Effects
COMMON
- •Fever, chills (signs of infection)
- •Fever, cough, shortness of breath, wheezing (signs of lung inflammation or pneumonia)
- •High blood sugar
- •Loss of appetite
- •Changes in taste
- •Headache
- •Nosebleeds
- •Cough
- •Mouth sores
- •Stomach problems including nausea or diarrhea
- •Skin rash
- •Itching
- •Feeling weak or tired
- •Tiredness, shortness of breath, dizziness, pale skin (signs of low red blood cells, anemia)
- •Swelling of arms, hands, feet, ankles, or other body parts (signs of edema)
- •Weight loss
- •High blood fat levels (high cholesterol)
- •Excessive thirst, increased urination, increased appetite with weight loss, tiredness (signs of diabetes)
- •Bleeding, for example in the intestinal wall
- •Significantly reduced urine output (sign of kidney failure)
- •Spontaneous bleeding or bruising (signs of low platelet count)
- •Shortness of breath (dyspnea)
- •Thirst, low urine output, dark urine, dry, red skin, irritability (signs of dehydration)
- •Sleep problems (insomnia)
- •Headache, dizziness (signs of high blood pressure)
- •Swelling in part or all of the arm (including fingers) or leg (including toes), feeling of heaviness, limited movement, discomfort (possible signs of lymphedema)
- •Fever due to infection, sore throat or mouth sores (signs of low white blood cells in blood, leukopenia, lymphopenia, and/or neutropenia)
- •Fever
- •Inflammation of the mucous membranes in the mouth, stomach, or intestines
- •Dry mouth
- •Heartburn (dyspepsia)
- •Vomiting
- •Difficulty swallowing (dysphagia)
- •Stomach pain
- •Acne
- •Rash and pain on palms and soles (hand-foot syndrome)
- •Skin redness (erythema)
- •Joint pain
- •Mouth pain
- •Menstrual disorders, such as irregular periods
- •High blood fat levels (high lipids, high triglycerides)
- •Low potassium in blood (hypokalemia)
- •Low phosphate in blood (hypophosphatemia)
- •Low calcium in blood (hypocalcemia)
- •Dry skin, flaky skin, skin damage
- •Nail changes, brittle nails
- •Mild hair loss
- •Abnormal liver function test results (increased alanine and aspartate aminotransferase levels)
- •Abnormal kidney function test results (increased creatinine levels)
- •Eyelid swelling
- •Protein in urine
RARE
- •Fever, rash, joint pain and inflammation, fatigue, loss of appetite, nausea, yellow skin, upper right abdominal pain, pale stools, dark urine (may be signs of reactivated Hepatitis B)
- •Shortness of breath, difficulty breathing when lying down, swelling of feet and ankles (signs of heart failure)
- •Swelling and/or pain in one leg, usually the calf, redness or warmth of the skin in this area (signs of a blood clot in the leg vein)
- •Sudden shortness of breath, chest pain, and coughing up blood (possible signs of a pulmonary embolism, a condition caused by a blockage in one or more lung arteries)
- •Significantly reduced urine output, swelling of the legs, confusion, and back pain (signs of acute kidney failure)
- •Rash, itching, hives, difficulty breathing or swallowing, dizziness (signs of a severe allergic reaction or hypersensitivity)
- •Feeling weak, spontaneous bleeding and bruising, and frequent infections with symptoms like fever, chills, sore throat, or mouth sores (signs of low blood cell count or pancytopenia)
- •Loss of taste (ageusia)
- •Coughing up blood (hemoptysis)
- •Menstrual disorders, such as absence of menstruation (amenorrhea)
- •Urinating more often during the day
- •Chest pain
- •Abnormal wound healing
- •Hot flashes
- •Watery, itchy, and red eyes, conjunctivitis
- •Shortness of breath or rapid breathing (signs of acute respiratory distress syndrome)
- •Fatigue, shortness of breath, dizziness, pale skin (signs of low red blood cell count, possibly due to pure red cell aplasia anemia)
- •Swelling of the face, around the eyes, inside the mouth and/or throat, and tongue, difficulty breathing and swallowing (angioedema), which can be signs of an allergic reaction
Important Warnings
- Do not take this medicine if you are allergic to everolimus, similar substances like sirolimus or temsirolimus, or any other ingredient in this medicine.
- Tell your doctor if you have liver problems, as your dose may need to be changed.
- This medicine can increase blood sugar and worsen diabetes. Tell your doctor if you feel very thirsty or need to urinate more often.
- You should not get vaccinated while taking this medicine.
- This medicine can increase cholesterol and other fats in your blood.
Show 13 more warnings
- Tell your doctor if you've had a major surgery recently or if your surgical wound hasn't healed, as this medicine can affect wound healing.
- If you have an infection, it might need to be treated before you start this medicine.
- Tell your doctor if you have had Hepatitis B, as it can reactivate during treatment.
- Tell your doctor if you have had or will have radiation therapy.
- This medicine can weaken your immune system, making you more prone to infections. Talk to your doctor if you have fever or other signs of infection.
- This medicine can affect your kidney function, so your doctor will monitor your kidneys.
- This medicine can cause shortness of breath, cough, and fever.
- This medicine can cause mouth sores. Your doctor might pause or stop treatment. You might need mouthwash or gel, but don't use any without asking your doctor first.
- Avoid grapefruit and grapefruit juice while taking this medicine, as they can increase the amount of medicine in your blood to harmful levels.
- This medicine is not recommended during pregnancy as it can harm the fetus. Use effective contraception during and for 8 weeks after treatment. Do not breastfeed during treatment or for 2 weeks after the last dose.
- This medicine can make you feel tired, so be careful when driving or using machines.
- This medicine contains lactose. If you have a sugar intolerance, talk to your doctor before taking it.
- Stop taking this medicine and get medical help right away if you have signs of an allergic reaction: trouble breathing or swallowing, swelling of your face, lips, tongue, or throat, or severe itchy skin with red rash or bumps.