Everolimus Sandoz
Everolimus Sandoz is a cancer medicine that works by reducing the blood supply to tumors and slowing down the growth and spread of cancer cells.
Form
tabletti
Strength
5 mg
Active Ingredient
Everolimus
Manufacturer
Sandoz A/S
How to Use
Dosage
The usual dose is 10 mg once a day. Your doctor will tell you how many tablets to take.
Method
Take Everolimus Sandoz once a day at about the same time, with or without food. Swallow the tablet(s) whole with a glass of water. Do not chew or crush the tablets.
Important
The maximum recommended daily dose is 10 mg.
Possible Side Effects
COMMON
- •Fever, chills (signs of infection)
- •Fever, cough, difficulty breathing, wheezing (signs of lung inflammation/pneumonia)
- •High blood sugar
- •Loss of appetite
- •Taste changes
- •Headache
- •Nosebleed
- •Cough
- •Mouth sores
- •Upset stomach, including nausea or diarrhea
- •Rash
- •Itching
- •Feeling weak or tired
- •Tiredness, shortness of breath, dizziness, pale skin (signs of low red blood cells, anemia)
- •Swelling of arms, hands, feet, ankles, or other body parts (signs of fluid retention/edema)
- •Weight loss
- •High blood fat levels (high cholesterol)
- •Easy bleeding or bruising (signs of low platelet count)
- •Shortness of breath
- •Thirst, low urine output, dark urine, dry, red skin, irritability (signs of dehydration)
- •Sleep problems (insomnia)
- •Headache, dizziness (signs of high blood pressure)
- •Swelling in parts of arms (including fingers) or legs (including toes), feeling of heaviness, limited movement, discomfort (possible signs of lymphedema)
- •Fever due to infection, sore throat, or mouth sores (signs of low white blood cells)
- •Fever
- •Inflammation in the lining of the mouth, stomach, or intestines
- •Dry mouth
- •Heartburn (indigestion)
- •Vomiting
- •Difficulty swallowing
- •Stomach pain
- •Acne
- •Rash and pain in palms and soles (hand-foot syndrome)
- •Skin redness (erythema)
- •Joint pain
- •Mouth pain
- •Menstrual problems, such as irregular periods
- •High blood fat levels (high lipids, high triglycerides)
- •Low potassium in blood
- •Low phosphate in blood
- •Low calcium in blood
- •Dry skin, flaky skin, skin damage
- •Nail changes, brittle nails
- •Mild hair loss
- •Abnormal liver function test results (increased ALT and AST)
- •Abnormal kidney function test results (increased creatinine)
- •Eyelid swelling
- •Protein in urine
RARE
- •Fever, rash, joint pain and inflammation, tiredness, loss of appetite, nausea, yellow skin, upper right abdominal pain, pale stools, dark urine (signs of Hepatitis B reactivation)
- •Shortness of breath, difficulty breathing when lying down, swelling of legs and feet (signs of heart failure)
- •Swelling and/or pain in one leg, usually the calf, skin redness or warmth in this area (signs of blood clot in leg vein)
- •Sudden difficulty breathing, chest pain, and coughing up blood (possible signs of pulmonary embolism, a blockage in a lung artery)
- •Significantly reduced urine output, leg swelling, confusion, and back pain (signs of sudden kidney failure)
- •Rash, itching, hives, difficulty breathing and swallowing, dizziness (signs of severe allergic reaction)
- •Weakness, spontaneous bleeding or bruising and frequent infections with symptoms like fever, chills, sore throat or mouth sores (signs of low levels of several blood cells, pancytopenia)
- •Loss of taste
- •Coughing up blood
- •Menstrual problems, such as missed periods
- •Frequent daytime urination
- •Chest pain
- •Abnormal wound healing
- •Hot flashes
- •Watery eyes with itching and redness, red eyes (conjunctivitis)
- •Shortness of breath or rapid breathing (signs of acute respiratory distress syndrome)
- •Tiredness, shortness of breath, dizziness, pale skin (signs of low red blood cells, possibly a type of anemia called erythroblastopenia)
- •Swelling of face, around eyes, mouth and inside mouth and/or throat and tongue, and difficulty breathing or swallowing (angioedema, signs of an allergic reaction)
Important Warnings
- Do not take this medicine if you are allergic to everolimus, similar substances like sirolimus or temsirolimus, or any other ingredients.
- Inform your doctor if you have liver problems, as your dose might need to be adjusted.
- Tell your doctor if you have diabetes or high blood sugar, as this medicine can make it worse.
- Do not get vaccinated while taking this medicine without talking to your doctor.
- This medicine can increase cholesterol and fat levels in your blood, so tell your doctor if you have high cholesterol.
Show 11 more warnings
- If you've had recent surgery or have unhealed wounds, this medicine might make wound healing harder.
- If you have an infection, it might need to be treated before starting this medicine.
- If you have a history of Hepatitis B, this medicine might reactivate it.
- Inform your doctor if you have received or will receive radiation therapy.
- This medicine can weaken your immune system, making you more prone to infections. Contact your doctor if you have fever or other signs of infection.
- This medicine can affect your kidney function, so your doctor will monitor it.
- This medicine can cause mouth sores. Your doctor might pause or stop treatment, or recommend special mouthwash or gel. Do not use any product without asking your doctor first.
- Avoid grapefruit and grapefruit juice while taking this medicine, as they can increase the amount of everolimus in your blood to a harmful level.
- This medicine is not recommended during pregnancy as it may harm the fetus. Women who can become pregnant must use very effective birth control during treatment and for 8 weeks after stopping.
- Do not breastfeed while taking this medicine or for 2 weeks after the last dose, as it may harm the baby.
- This medicine contains lactose. If you have a sugar intolerance, talk to your doctor before taking it.