Estrofem
Estrofem is a hormone replacement therapy (HRT) medicine that helps relieve menopausal symptoms like hot flashes for women whose periods have stopped.
How to Use
Dosage
Take one tablet every day.
Method
Take the tablet whole, with or without food, at roughly the same time each day. When you finish one 28-day pack, start a new one right away.
Do not take more than one 1 mg tablet per day.
Possible Side Effects
- •Depression
- •Headache
- •Abdominal pain
- •Nausea
- •Leg cramps
- •Breast pain, tenderness, or enlargement
- •Swelling (fluid retention)
- •Weight gain
- •Allergic reaction (symptoms like hives, itching, swelling, difficulty breathing, low blood pressure, dizziness, sweating)
- •Vision problems
- •Blood clots in veins (venous thromboembolism)
- •Heartburn (digestive issues)
- •Vomiting
- •Flatulence or abdominal bloating
- •Gallstones
- •Itching or hives
- •Irregular vaginal bleeding
- •Worsening of migraine
- •Stroke
- •Insomnia
- •Epilepsy
- •Changes in sex drive
- •Vaginal yeast infection
- •Worsening of asthma
- •Dizziness
- •Diarrhea
- •Hair loss (alopecia)
- •High blood pressure
Important Warnings
- Do not take if you have or have had breast cancer, or if it is suspected.
- Do not take if you have or have had a cancer sensitive to estrogen, like uterine lining cancer, or if it is suspected.
- Do not take if you have unexplained vaginal bleeding.
- Do not take if you have untreated thickening of the uterine lining (endometrial hyperplasia).
- Do not take if you have or have had a blood clot in a vein, such as in the legs (deep vein thrombosis) or lungs (pulmonary embolism).
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- Do not take if you have a blood clotting disorder (e.g., protein C, protein S, or antithrombin deficiency).
- Do not take if you have or recently had a disease caused by blood clots in arteries, such as a heart attack, stroke, or angina.
- Do not take if you have or have had liver disease and your liver function tests are not yet normal.
- Do not take if you have a rare inherited blood disorder called porphyria.
- Do not take if you are allergic to estradiol or any other ingredient in Estrofem.
- Stop taking the medicine and contact your doctor immediately if your skin or eyes turn yellow (jaundice), as this may indicate liver problems.
- Stop taking the medicine and contact your doctor immediately if your blood pressure increases significantly (symptoms may include headache, tiredness, and dizziness).
- Stop taking the medicine and contact your doctor immediately if you experience swelling of the face, tongue, and/or throat, difficulty swallowing, or hives with breathing problems, as these may be signs of angioedema.
- Stop taking the medicine and contact your doctor immediately if you get a migraine-like headache for the first time.
- Stop taking the medicine and contact your doctor immediately if you become pregnant.
- Stop taking the medicine and contact your doctor immediately if you experience symptoms of a blood clot, such as painful swelling and redness in the legs, sudden chest pain, or difficulty breathing.
Use in Elderly Patients
The classification depends on the dosage form. Systemic use (for example estrogen patch, tablet, gel): Avoid use in older adults. In systemic use, consider potential adverse effects, such as risk of cardiovascular diseases and venous thromboembolism. Consider potential interactions. Topical treatment of the vagina: Suitable for older adults. No significant systemic absorption. (updated 21.10.2024)