Enalapril/Lercanidipine Krka
Enalapril/Lercanidipine Krka is a medicine that combines two drugs, enalapril and lercanidipine, to help lower high blood pressure.
Form
tabletti, kalvopäällysteinen
Strength
20 mg / 10 mg
Active Ingredient
Lercanidipine hydrochloride
Manufacturer
KRKA d.d. Novo mesto
How to Use
Dosage
The usual dose is one tablet once a day.
Method
Take one tablet whole with water in the morning, at least 15 minutes before breakfast.
Important
Do not take more than one tablet per day as prescribed by your doctor.
Possible Side Effects
COMMON
- •Cough
- •Dizziness
- •Headache
RARE
- •Changes in blood test results (like low platelets or high potassium)
- •Nervousness or anxiety
- •Feeling dizzy when standing up
- •Feeling like the world is spinning (vertigo)
- •Fast or irregular heartbeat (palpitations)
- •Sudden redness of the face, neck, or upper chest (flushing)
- •Low blood pressure
- •Stomach pain
- •Constipation
- •Nausea
- •High liver enzyme levels (seen in blood tests)
- •Reddened skin
- •Joint pain
- •More frequent urination
- •Feeling weak or tired
- •Feeling hot
- •Swollen ankles
- •Anemia (low red blood cells)
- •Allergic reactions
- •Ringing in the ears (tinnitus)
- •Fainting
- •Dry throat
- •Sore throat
- •Indigestion
- •Salty taste in the mouth
- •Diarrhea
- •Dry mouth
- •Swollen gums
- •Serious allergic reaction with swelling of the face, lips, tongue, or throat, causing difficulty breathing or swallowing
- •Hives (itchy rash)
- •Waking up at night to urinate
- •Large amount of urine production
- •Impotence (difficulty getting or keeping an erection)
Important Warnings
- Do not take if you are allergic to enalapril, lercanidipine, or any other ingredients in this medicine.
- Do not take if you have had severe swelling (angioedema) of your face, lips, tongue, or throat, especially if it was from similar blood pressure medicines (ACE inhibitors or calcium channel blockers).
- Do not take if you have diabetes or kidney problems AND are taking a blood pressure medicine called aliskiren.
- Do not take if you are pregnant (especially after the first 3 months) or if you are breastfeeding.
- Do not take if you have serious heart conditions like untreated heart failure, narrowing of heart valves, unstable chest pain, or had a heart attack in the last month.
Show 14 more warnings
- Do not take if you have severe liver or kidney problems, or if you are on dialysis.
- Do not take if you are taking sacubitril/valsartan (a medicine for heart failure), as it increases the risk of severe swelling.
- Do not take if you are taking certain medicines (like antifungals ketoconazole, itraconazole; macrolide antibiotics erythromycin, clarithromycin; antivirals ritonavir; ciclosporin) or consuming grapefruit/grapefruit juice, as they can interfere with this medicine.
- Tell your doctor if you have low blood pressure, feel weak or dizzy when standing up, or if you've had severe vomiting, diarrhea, or dehydration recently.
- Tell your doctor if you are on a salt-restricted diet.
- Tell your doctor if you have heart problems, a stroke, or kidney problems (including a kidney transplant) or liver problems.
- Tell your doctor if you have blood disorders (e.g., low white blood cells, platelets, or red blood cells) or a connective tissue disease (like lupus), or if you are taking medicines that suppress your immune system.
- If you are of Black origin, be aware there is a higher risk of allergic reactions (swelling of the face, lips, tongue, or throat) with this type of medicine.
- Tell your doctor if you have diabetes, as your blood sugar and potassium levels will be closely watched.
- Tell your doctor if you are taking potassium supplements or salt substitutes that contain potassium.
- Tell your doctor if you are over 70 years old or cannot tolerate certain sugars (like lactose).
- Tell your doctor if you are taking other blood pressure medicines like ARBs (e.g., valsartan, telmisartan, irbesartan) or aliskiren.
- Tell your doctor if you are taking racecadotril (for diarrhea), temsirolimus, sirolimus, everolimus (for organ transplants or cancer), or vildagliptin (for diabetes), as these can increase the risk of severe swelling.
- Tell your doctor if you are having surgery (even at the dentist), a procedure to remove cholesterol from your blood (LDL apheresis), or treatment for bee or wasp sting allergies.
Use in Elderly Patients
Category A
Suitable for older adults. Do not use in severe renal impairment. Significant adverse effects include ankle oedema and orthostatic hypotension. Consider potential interactions. Avoid grapefruit. (updated 17.2.2025)