Enalapril Comp Orion
Enalapril Comp Orion is a medicine containing enalapril and hydrochlorothiazide, used to treat high blood pressure.
Form
tabletti
Strength
20 mg / 12.5 mg
Active Ingredient
Enalapril maleate
Manufacturer
Orion Corporation
How to Use
Dosage
Typically, one tablet once a day. If needed, the dose can be increased to two tablets once a day.
Method
Take the tablet with water, with or without food.
Important
Two tablets once daily.
Possible Side Effects
COMMON
- •Dizziness, weakness, or feeling unwell
- •Nausea
- •Blurred vision
- •Cough
- •Low blood pressure, fainting, changes in heart rhythm, rapid heartbeats, chest pain or angina
- •Headache
- •Taste changes
- •Shortness of breath
- •Diarrhea or stomach pain
- •Skin rash
- •Fatigue
- •Depression
- •Allergic reactions, such as swelling of the face, lips, tongue, or throat, which may cause difficulty breathing and/or swallowing
- •High or low blood potassium, high cholesterol, triglycerides, uric acid, or creatinine levels (seen in blood tests)
- •Muscle cramps
RARE
- •Sudden drop in blood pressure
- •Fast or irregular heartbeat (palpitations)
- •Heart attack or stroke (possibly due to very low blood pressure in certain high-risk patients, including those with heart or brain circulatory problems)
- •Anemia
- •Confusion, insomnia or drowsiness, nervousness, tingling or numbness of the skin, vertigo
- •Ringing in the ears (tinnitus)
- •Runny nose, sore throat, hoarseness, asthma
- •Pancreatitis (inflammation of the pancreas)
- •Vomiting, indigestion, constipation, flatulence, loss of appetite
- •Irritated stomach, dry mouth, stomach ulcer
- •Impaired kidney function, kidney failure
- •Joint pain (arthralgia)
- •Increased sweating, itching or hives, hair loss
- •Redness
- •General feeling of being unwell
- •Fever
- •Impotence
- •High protein levels in urine (detected by urine test)
- •Gout
- •Decreased libido
- •Low blood sugar or blood sodium or magnesium levels, high blood urea levels (detected by blood test)
- •Raynaud's phenomenon (hands and feet become very cold and white due to reduced blood flow)
- •Changes in blood values (reduced white and red blood cells, low hemoglobin, decreased platelets)
- •Bone marrow depression
- •Autoimmune diseases
- •Strange dreams and sleep difficulties
- •Lung problems (infiltrates, nasal inflammation, pneumonia, breathing difficulties including pneumonitis and pulmonary edema)
- •Inflammation of cheeks, gums, tongue, lips, throat
- •Mouth sores
- •Decreased urine output
- •Severe skin reactions like erythema multiforme or Stevens-Johnson syndrome (redness, peeling, blisters, or skin detachment)
- •Liver problems (impaired function, hepatitis, jaundice, high liver enzymes or bilirubin)
- •Non-bacterial kidney inflammation (interstitial nephritis)
- •Enlarged breasts in men
- •High blood sugar
- •Muscle weakness (possibly due to low blood potassium)
- •Swelling of the intestinal wall (intestinal angioedema)
- •High blood calcium
- •Acute respiratory distress (severe shortness of breath, fever, weakness, and confusion)
- •Overproduction of antidiuretic hormone (fluid retention, weakness, fatigue, or confusion)
- •Symptom complex including fever, blood vessel inflammation, muscle pain, joint pain, rash, photosensitivity, or other skin reactions
- •Skin and lip cancer (non-melanoma skin cancer)
- •Impaired vision or eye pain due to high pressure (possible sign of fluid accumulation in the eye)
Important Warnings
- Stop taking this medicine and contact a doctor immediately if you experience swelling of the face, lips, tongue, or throat, which may cause difficulty breathing and/or swallowing.
- Stop taking this medicine and contact a doctor immediately if you experience swelling of the hands, feet, or ankles.
- Stop taking this medicine and contact a doctor immediately if you develop red, itchy raised bumps on the skin (hives).
- Do not take this medicine if you are allergic to enalapril maleate, other ACE inhibitors, hydrochlorothiazide, other sulfonamides, or any other ingredient in this medicine.
- Do not take this medicine if you are pregnant, especially if you are more than 3 months pregnant.
Show 4 more warnings
- Do not take this medicine if you have diabetes or kidney problems and are taking a blood pressure medicine containing aliskiren.
- Do not take this medicine if you are taking or have recently taken a combination medicine with sacubitril and valsartan for heart failure, as it increases the risk of serious swelling.
- Seek immediate medical attention if you previously had breathing difficulties or lung problems after taking hydrochlorothiazide and they recur after taking Enalapril Comp Orion.
- Contact your doctor if you experience blurred vision or eye pain. These can be symptoms of fluid build-up in the eye or increased eye pressure, which can lead to permanent vision loss if not treated.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Effectiveness is reduced in renal impairment. Consider risk of orthostatic hypotension and hyponatraemia and -kalemia. (updated 19.5.2025)