Edoxaban Zentiva

Edoxaban Zentiva is a medicine that helps prevent and treat blood clots in the brain, other body blood vessels, leg veins, and lungs.

Form
tabletti, kalvopäällysteinen
Strength
15 mg
Active Ingredient
Edoxaban tosylate monohydrate
Manufacturer
Zentiva k.s.

How to Use

Dosage

The usual dose is one 60 mg tablet once daily; your doctor may prescribe a 30 mg tablet once daily if you have kidney problems, weigh 60 kg or less, or take certain other medicines.

Method

Swallow the tablet whole with water, with or without food. If you have trouble swallowing, the tablet can be crushed and mixed with water or apple sauce right before taking.

Important

Do not take more than one 60 mg tablet in a single day, unless directed otherwise by your doctor for a reduced dose (30 mg).

Possible Side Effects

COMMON
  • Stomach pain
  • Abnormal liver test results
  • Bleeding from or under the skin
  • Anemia (low red blood cell count)
  • Nosebleed
  • Vaginal bleeding
  • Rash
  • Intestinal bleeding
  • Bleeding from the mouth and/or throat
  • Blood in urine
  • Bleeding after an injection
  • Stomach bleeding
  • Dizziness
  • Nausea
  • Headache
  • Itching
RARE
  • Bleeding in the eyes
  • Bleeding from a surgical wound after an operation
  • Coughing up blood
  • Brain bleeding
  • Other types of bleeding
  • Low number of platelets in the blood (which can affect clotting)
  • Allergic reaction
  • Hives
  • Bleeding in muscles
  • Bleeding in joints
  • Bleeding in the abdominal cavity
  • Bleeding in the heart
  • Intracranial bleeding
  • Bleeding after a surgical procedure
  • Anaphylactic shock (severe allergic reaction)
  • Swelling in any part of the body due to an allergic reaction
  • Kidney bleeding, sometimes with blood in the urine, leading to kidney problems

Important Warnings

  • Do not take if you are allergic to edoxaban or any other ingredient in this medicine.
  • Do not take if you are currently bleeding.
  • Do not take if you have a condition that increases your risk of severe bleeding, such as a stomach ulcer, brain injury, or recent brain or eye surgery.
  • Do not take if you are taking other medicines to prevent blood clotting (e.g., warfarin, dabigatran, rivaroxaban, apixaban, or heparin), unless switching treatments under medical supervision.
  • Do not take if you have a liver disease that increases your bleeding risk.
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  • Do not take if you have uncontrolled high blood pressure.
  • Do not take if you are pregnant or breastfeeding.
  • Inform your doctor if you have end-stage kidney disease, are on dialysis, or have a mechanical heart valve, as this medicine may not be suitable.
  • Tell your doctor if you have antiphospholipid syndrome, a condition that may increase your risk of blood clots.
  • If you need surgery, it is very important to tell your doctor or dentist that you are taking Edoxaban Zentiva, as you may need to stop taking it for a short time before the procedure.