Dopital
Dopital is a medicine containing mexiletine hydrochloride used to treat rare and severe heart rhythm problems in adults.
Form
kapseli, kova
Strength
200 mg
Active Ingredient
Mexiletine hydrochloride
Manufacturer
Macure Pharma ApS
How to Use
Dosage
Your doctor will usually start you on 400 mg (two 200 mg capsules). After this, the usual maintenance dose is 150-300 mg three times a day.
Method
Swallow the capsules whole without chewing, with plenty of liquid, preferably sitting or standing to avoid irritation.
Important
The maximum daily dose is 1200 mg (six 200 mg capsules). Do not take more than 300 mg at one time.
Possible Side Effects
COMMON
- •Stomach pain
- •Indigestion
- •Insomnia (difficulty sleeping)
- •Dizziness
- •Tremor (shaking)
- •Drowsiness
- •Headache
- •Tingling in arms and legs
- •Blurred vision
- •Loss of balance (vertigo)
- •Numbness
- •Ringing in the ears (tinnitus)
- •Fast heart rate
- •Palpitations (feeling your heartbeat)
- •Chest pain (angina)
- •Abnormal heart rhythm (atrial fibrillation)
- •Flushing (redness of the face/skin)
- •Low blood pressure (can cause dizziness and fainting)
- •Nausea (feeling sick)
- •Constipation
- •Dry mouth
- •Acne
- •Arm and leg pain
- •Fatigue
- •Weakness
- •Chest discomfort
- •General discomfort or malaise
- •Rash
- •Difficulty controlling movements (ataxia)
RARE
- •Seizures
- •Speech disorders
- •Slow heart rate
- •Memory loss (amnesia)
- •Loss of consciousness (fainting)
- •Hiccups
- •Hair loss
- •Joint pain
- •Dry skin
- •Abnormal liver values (shown in blood tests)
- •Erectile dysfunction (difficulty getting or keeping an erection)
- •Liver dysfunction (shown in blood tests)
- •Severe decrease in white blood cells (increases infection risk)
- •Heart failure
- •Liver damage, including hepatitis (inflammation of the liver)
Important Warnings
- Do not use Dopital if you are allergic to mexiletine hydrochloride or any other ingredients in this medicine.
- Do not use if you are allergic to local anaesthetics like lidocaine.
- Do not use if you have certain severe heart rhythm problems (like sick sinus syndrome or very slow heartbeat) unless you have a pacemaker.
- Do not use if you have a hereditary long QT syndrome (other than type 3) that can cause severe rhythm problems.
- Seek immediate medical help if you experience a severe allergic reaction (e.g., severe rash with fever) or sudden changes in heart rhythm (e.g., very fast or slow heart rate, chest pain, dizziness, fainting).
Show 1 more warnings
- Talk to your doctor if you have heart, liver, or kidney problems, abnormal potassium levels, or a history of seizures.