Dopital
Dopital is a medicine used to treat rare and serious heart rhythm problems in adults.
Form
kapseli, kova
Strength
50 mg
Active Ingredient
Mexiletine hydrochloride
Manufacturer
Macure Pharma ApS
How to Use
Dosage
Your doctor might start you on 400 mg (two 200 mg capsules), then adjust to 150-300 mg three times a day.
Method
Swallow capsules whole with liquid, without chewing, preferably upright and after food to avoid stomach upset.
Important
The maximum recommended daily dose is 1200 mg (six 200 mg capsules).
Possible Side Effects
COMMON
- •Abdominal pain
- •Indigestion
- •Difficulty sleeping
- •Dizziness
- •Tremor
- •Drowsiness
- •Headache
- •Tingling in arms and legs
- •Blurred vision
- •Feeling of losing balance
- •Numbness
- •Ringing in ears (tinnitus)
- •Fast heart rate
- •Heart palpitations (feeling your own heart beating)
- •Chest pain (angina pectoris)
- •Abnormal heart rhythm (atrial fibrillation)
- •Redness
- •Low blood pressure (can cause dizziness and fainting)
- •Nausea
- •Constipation
- •Dry mouth
- •Acne
- •Arm and leg pain
- •Fatigue
- •Weakness
- •Chest discomfort
- •General feeling of being unwell
- •Rash
- •Difficulty controlling movements (ataxia)
RARE
- •Seizures
- •Speech disorders
- •Slow heart rate
- •Memory loss (amnesia)
- •Loss of consciousness
- •Hiccups
- •Hair loss
- •Joint pain
- •Dry skin
- •Abnormal liver function test results
- •Erectile dysfunction
- •Liver dysfunction (shown in blood tests)
- •Severe decrease in white blood cells (increases infection risk)
- •Heart failure
- •Liver damage, including liver inflammation (hepatitis)
- •Decrease in platelets (increases bleeding/bruising risk)
- •Lupus-like syndrome (joint pain, rash, fever)
- •Red and peeling skin
- •Hallucinations (seeing or hearing things that are not there)
- •Temporary confusion or difficulty concentrating
- •Double vision
- •Taste changes
- •Heart rhythm disorders
- •Severe drop in blood pressure (collapse)
- •Hot flashes
- •Lung scarring causing shortness of breath (pulmonary fibrosis)
- •Diarrhea
- •Vomiting
- •Esophageal damage
Important Warnings
- Do not take Dopital if you are allergic to mexiletine hydrochloride, any other ingredient, or local anesthetics like lidocaine.
- Do not take Dopital if you have certain heart problems that cause a slow heart rate (unless you have a pacemaker), shortness of breath, swollen ankles, or severe heart rhythm problems like long QT syndrome (type 3 excluded).
- Tell your doctor if you have heart, liver, or kidney problems, or if your blood potassium levels are too high or too low.
- Tell your doctor if you have a history of seizures or abnormal blood test results.
- Tell your doctor if you have a gene variation that makes you break down certain medicines slowly, as your dose might need to be adjusted.
Show 7 more warnings
- Tell your doctor if you are taking other medicines that can affect your heart rate.
- Dopital is not for children or teenagers under 18 years old.
- Tell your doctor if you start or stop smoking while on Dopital, as it can change the medicine's effect.
- Limit your caffeine intake by half while taking Dopital, as it can raise caffeine levels in your blood.
- Do not use Dopital if you are pregnant or breastfeeding without discussing it with your doctor.
- Do not drive or use machines until you know how Dopital affects you, as it can impair your abilities.
- Seek immediate medical help if you experience a severe allergic reaction (rash, fever), serious heart rhythm problems (fast/slow heart rate, chest pain, difficulty breathing, dizziness, sweating, fainting), DRESS reaction (skin blisters, unwell, fever), or Stevens-Johnson syndrome (severe rash with blisters in eyes, mouth).