Ditrim duplo
Ditrim duplo is an antibiotic containing trimethoprim and sulfadiazine, which stops the growth of susceptible bacteria, often used to treat respiratory, ear, and urinary tract infections in children.
Form
oraalisuspensio
Strength
16 mg/ml + 50 mg/ml
Active Ingredient
Trimethoprim
Manufacturer
Orion Corporation
How to Use
Dosage
Take this medicine exactly as your doctor has prescribed.
Method
Take orally, and drink plenty of fluids during treatment to prevent kidney stones.
Important
Always follow your doctor's instructions for the maximum daily dose.
Possible Side Effects
COMMON
- •Nausea
- •Vomiting
- •Diarrhea
- •Inflammation of the tongue
- •Rash (exanthema)
- •Itching
RARE
- •Allergic symptoms (e.g., hives, fever, or swollen mucous membranes)
- •Shortness of breath
- •High fever
- •Blood in urine
- •Bloody or otherwise severe diarrhea
- •Increased number of eosinophilic white blood cells
- •Decreased number of white blood cells
- •Hives
- •Vitamin B12 or folic acid deficiency
- •Anemia
- •Decreased granulocytes (a type of white blood cell)
- •Decreased number of all blood cells
- •Decreased platelets
- •Life-threatening allergic reaction (anaphylaxis)
- •Sudden localized swelling in the skin, mucous membranes, or internal organs (angioedema)
- •Serum sickness
- •Allergic and hypersensitivity reactions (e.g., hives, fever, swollen mucous membranes)
- •Increased blood potassium and decreased blood sodium levels
- •Meningitis (inflammation of the membranes around the brain and spinal cord)
- •Conjunctivitis (inflammation of the eye's conjunctiva)
- •Uveitis (inflammation of the eye's uvea)
- •Lung changes (lung infiltrates)
- •Severe large intestine inflammation, stomatitis (mouth inflammation)
- •Gallbladder obstruction (cholestasis)
- •Necrotic liver damage
- •Various severe or even life-threatening rashes, such as Stevens-Johnson syndrome (SJS), photosensitivity
- •Muscle pain
- •Acute kidney inflammation, crystalluria (crystals in urine)
- •Toxic epidermal necrolysis (TEN)
- •Acute generalized exanthematous pustulosis (AGEP), with symptoms like fever, skin redness, and pus-filled blisters
- •Blood clotting disorder, vascular disease
- •Allergic myocarditis (inflammation of heart muscle)
- •Depression
- •Hallucinations
- •Difficulty coordinating muscle movements, brain disease
- •Headache
- •Insomnia
- •Convulsions
- •Vertigo (dizziness)
- •Nerve inflammation
- •Ringing in the ears
- •Loss of appetite
- •Liver inflammation
- •Changes in liver enzyme levels
- •Joint pain
- •Kidney stones
- •Drug fever, chills
- •Purplish, raised, painful sores on limbs, sometimes on face and neck, with fever (Sweet's syndrome)
- •Systemic eosinophilic syndrome (DRESS syndrome)
Important Warnings
- Discuss with your doctor if you have had allergic reactions (such as hives, fever, or swollen mucous membranes) to other antibiotics.
- Discuss with your doctor if you have developed a rash or other allergic symptoms when using sulfa medicines (e.g., sulfonylureas for diabetes).
- Inform your doctor if you have HIV infection, as HIV patients have a higher risk of hypersensitivity reactions to sulfa antibiotics.
- Inform your doctor if you have mild or moderate kidney failure.
- Inform your doctor if you have folate deficiency, as folic acid supplements might be needed during treatment.
Show 11 more warnings
- This medicine affects folate balance and can harm blood cell production, especially with long-term or high doses. Contact your doctor immediately if you get a sore throat, fever, paleness, or red/purple skin discoloration, as these can be signs of serious blood problems.
- This medicine can cause sensitivity to light, so avoid direct sun exposure.
- If you develop bloody or severe diarrhea during treatment, stop using Ditrim duplo immediately and contact your doctor.
- Be aware of potentially life-threatening skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS syndrome). These often start as red, target-like spots or blisters on the body, with other symptoms like mouth sores or red, swollen eyes, and flu-like illness. Stop treatment and contact your doctor immediately if these symptoms appear.
- If you experience fever, red skin, and pus-filled blisters, these might be signs of a serious reaction called acute generalized exanthematous pustulosis (AGEP); contact your doctor.
- If you have had severe skin reactions (like Stevens-Johnson syndrome, TEN, DRESS, or AGEP) with Ditrim duplo before, you must never use this medicine again.
- Tell your doctor immediately if your cough unexpectedly worsens and you have difficulty breathing.
- Rarely, severe immune reactions (HLH) have occurred. Seek immediate medical attention if you experience fever, swollen lymph nodes, weakness, dizziness, shortness of breath, bruising, or rash simultaneously or close together.
- Using Ditrim duplo with certain medicines, potassium supplements, or high-potassium foods can lead to high blood potassium. Symptoms can include muscle cramps, irregular heartbeat, diarrhea, nausea, dizziness, or headache.
- Your doctor may need to monitor your child's kidney function and blood values, especially during long-term use.
- Always tell your doctor if your child has other illnesses or allergies.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Contraindicated in case of severe hepatic impairment. Reduce the dose in severe renal impairment. Consider the risks when used in combination with medicines that predispose to hyperkalaemia and are myelotoxic. (updated 6.11.2023)