Dimethyl fumarate Orion
Dimethyl fumarate Orion is a medicine that treats relapsing-remitting multiple sclerosis (MS) in people aged 13 and older by helping to protect the brain and spinal cord from immune system damage.
Form
enterokapseli, kova
Strength
240 mg
Active Ingredient
Dimethyl fumarate
Manufacturer
Orion Corporation
How to Use
Dosage
Starting dose: 120 mg twice a day for the first 7 days. After that, the usual dose is 240 mg twice a day.
Method
Swallow the capsules whole with water. Do not divide, crush, dissolve, suck, or chew the capsules. Take with food.
Important
The maximum daily dose is 480 mg.
Possible Side Effects
COMMON
- •Facial flushing, feeling warm, hot, burning, or itchy
- •Diarrhea
- •Nausea
- •Stomach pain or cramps
- •Stomach flu (gastroenteritis)
- •Vomiting
- •Indigestion
- •Stomach inflammation (gastritis)
- •Rash
- •Red or pink patches on the skin (erythema)
- •Hair loss (alopecia)
- •Low white blood cell count
- •Protein in urine
- •High liver enzymes in blood
- •Headache
- •Sore throat
- •Cough
- •Painful periods
RARE
- •Allergic reactions
- •Low platelet count
- •Liver inflammation and high liver enzymes
- •Shingles (blisters, tingling, itching, or pain on one side of the body or face, fever, weakness, numbness, red patches)
- •Severe runny nose
Important Warnings
- Do not take this medicine if you are allergic to dimethyl fumarate or any other ingredient, or if you have or suspect a rare brain infection called PML.
- Your doctor will do regular blood tests to check your white blood cell count, kidneys, and liver, as this medicine can affect them.
- Tell your doctor if you have severe kidney or liver disease, stomach or bowel problems, or a serious infection like pneumonia.
- Tell your doctor right away if you think you have shingles, which is a viral infection that can occur with this medicine.
- Contact your doctor immediately if your MS symptoms worsen or you notice new symptoms, as these could be signs of a rare, very serious brain infection called PML.
Show 4 more warnings
- If you notice you're urinating more, are very thirsty, have weak muscles, bone pain, or fractures, tell your doctor quickly, as these could be signs of a rare kidney problem.
- Do not give this medicine to children under 10 years old.
- Avoid strong alcoholic drinks (over 30% alcohol) for one hour after taking this medicine, as it can cause stomach inflammation.
- Do not use this medicine if you are pregnant, unless your doctor says it is absolutely necessary.