Dimethyl fumarate 1A Farma
This medicine treats a type of multiple sclerosis (MS) by protecting the brain and spinal cord from damage, which can slow down the disease.
Form
enterokapseli, kova
Strength
120 mg
Active Ingredient
Dimethyl fumarate
Manufacturer
1A Farma A/S
How to Use
Dosage
Starting dose is 120 mg twice daily for 7 days, then the usual dose is 240 mg twice daily.
Method
Swallow the capsules whole with water; do not divide, crush, dissolve, suck, or chew. Take them with food to help reduce common side effects.
Important
The maximum daily dose is 480 mg.
Possible Side Effects
COMMON
- •Facial or body redness (flushing), feeling of warmth, heat, burning, or itching in the body
- •Diarrhea
- •Nausea
- •Stomach pain or cramps
- •Gastroenteritis (stomach flu)
- •Vomiting
- •Indigestion (dyspepsia)
- •Stomach lining inflammation (gastritis)
- •Gastrointestinal symptoms
- •Burning sensation
- •Hot flashes, feeling of heat
- •Itching (pruritus)
- •Rash
- •Pinkish or reddish patches on the skin (erythema)
- •Hair loss (alopecia)
- •Low white blood cell count (lymphopenia, leukopenia)
- •Protein (albumin) in urine
- •Increased liver enzyme levels (ALAT, ASAT) in blood
- •Ketones in urine (detected by urine tests)
RARE
- •Allergic reactions (hypersensitivity)
- •Decreased platelet count
- •Liver inflammation and increased liver enzyme levels (ALAT or ASAT with bilirubin)
- •Shingles (herpes zoster infection), with symptoms like blisters, skin tingling, itching, or pain usually on one side of the upper body or face, along with fever and weakness.
- •Severe, watery runny nose (rhinorrhea)
- •Swelling of face, lips, mouth, or tongue (angioedema)
- •Wheezing, breathing difficulties or shortness of breath (dyspnea, hypoxia)
- •Dizziness or loss of consciousness (hypotension)
Important Warnings
- Do not take this medicine if you are allergic to dimethyl fumarate or any other ingredient in this medicine.
- Do not take this medicine if you have or are suspected of having a rare brain infection called progressive multifocal leukoencephalopathy (PML).
- This medicine can affect your white blood cells, kidneys, and liver. Your doctor will take regular blood tests during treatment.
- Tell your doctor if you have severe kidney disease, liver disease, stomach or bowel disease, or a serious infection (e.g., pneumonia).
- If you get shingles or suspect symptoms of it, tell your doctor immediately.
Show 5 more warnings
- If your MS worsens or you notice new symptoms, contact your doctor immediately, as these could be signs of a serious brain infection (PML).
- If you urinate more often, are unusually thirsty, feel weak in your muscles, have bone fractures or pain, talk to your doctor as soon as possible.
- Do not use this medicine if you are pregnant unless your doctor considers it absolutely necessary.
- Avoid strong alcoholic drinks for one hour before and after taking this medicine, as it can cause stomach inflammation.
- This medicine should not be given to children under 10 years of age.