Dexketoprofen Krka
Dexketoprofen Krka is a pain-relieving medicine, an NSAID, used for acute moderate to severe pain when tablets cannot be taken.
Form
injektio-/infuusioneste, liuos
Strength
50 mg / 2 ml
Active Ingredient
Dexketoprofen trometamol
Manufacturer
KRKA d.d. Novo mesto
How to Use
Dosage
The recommended dose is usually one 50 mg ampoule every 8–12 hours.
Method
The medicine is given as an injection into a muscle or vein for acute pain, for a maximum of 2 days, then switch to oral pain relief.
Important
The total daily dose must not exceed 150 mg (three ampoules), or 50 mg (one ampoule) if you are elderly or have kidney or liver problems.
Possible Side Effects
COMMON
- •Nausea and/or vomiting
- •Pain, inflammation, bruising, or bleeding at the injection site
- •Blood vomiting
- •Low blood pressure
- •Fever, chills
- •Blurred vision
- •Dizziness, drowsiness
- •Sleep disturbances
- •Headache
- •Anemia
- •Abdominal pain
- •Constipation
- •Indigestion
- •Diarrhea
- •Dry mouth
- •Redness
- •Rash
- •Itching
- •Increased sweating
- •Fatigue
- •Pain
RARE
- •Stomach ulcer, bleeding, or perforation
- •High blood pressure
- •Fainting
- •Slow breathing rate
- •Superficial vein inflammation due to a blood clot
- •Heart rhythm disorders (extrasystoles), rapid heart rate
- •Swelling of hands and feet (peripheral edema), laryngeal edema
- •Abnormal sensations
- •Feverish feeling and chills
- •Ringing in the ears (tinnitus)
- •Itchy rash
- •Jaundice
- •Acne
- •Back pain
- •Kidney pain
- •Increased need to urinate
- •Menstrual disorders
- •Prostate problems
- •Muscle stiffness, joint stiffness, muscle cramps
- •Abnormal liver values (blood tests)
- •Increased blood sugar (hyperglycemia)
- •Decreased blood sugar (hypoglycemia)
- •High blood triglyceride levels (hypertriglyceridemia)
- •Ketones in urine (ketonuria)
- •Protein in urine (proteinuria)
- •Liver cell damage (hepatitis)
- •Acute kidney failure
- •Anaphylactic reaction (hypersensitivity reaction that can lead to loss of consciousness)
- •Ulceration of skin, mouth, eyes, and genital areas (Stevens-Johnson and Lyell syndrome)
- •Swelling of face, tongue, and throat (angioedema)
- •Difficulty breathing due to airway muscle spasms (bronchospasm)
- •Shortness of breath
- •Pancreatitis
- •Skin reactions and sun sensitivity
- •Kidney damage
- •Decreased white blood cells (neutropenia)
- •Decreased platelets (trombocytopenia)
Important Warnings
- Do not use this medicine if you are allergic to dexketoprofen, aspirin, or other NSAIDs, or if you have had asthma attacks, allergic rhinitis, nasal polyps, hives, angioedema, or breathing difficulties with these medicines.
- Do not use if you have stomach or duodenal ulcers, bleeding in your digestive tract, chronic digestive problems (like heartburn), or bowel inflammation (like Crohn's disease).
- Do not use if you have severe heart failure, moderate to severe kidney failure, or severe liver problems.
- Do not use if you have bleeding disorders or problems with blood clotting.
- Do not use if you are severely dehydrated due to vomiting, diarrhea, or not drinking enough fluids.
Show 10 more warnings
- Do not use during the last trimester of pregnancy or while breastfeeding; avoid use if you are planning to become pregnant or are pregnant.
- This medicine should not be used by children or adolescents (under 18 years of age).
- Tell your doctor if you are taking other medicines that increase the risk of stomach ulcers or bleeding (e.g., corticosteroids, antidepressants, blood thinners).
- Discuss with your doctor if you have heart problems, have had a stroke, or are at risk (e.g., high blood pressure, diabetes, high cholesterol, smoking).
- If you are elderly, the likelihood of side effects increases; contact your doctor immediately if you experience side effects.
- If you are a woman with fertility issues or trying to conceive, this medicine is not recommended as it may impair fertility.
- Tell your doctor if you have disorders in blood formation or blood cell production, or if you have systemic lupus erythematosus (SLE) or mixed connective tissue disease.
- This medicine can hide signs of infection; if you have an infection and symptoms persist or worsen, contact your doctor immediately.
- Stop using the medicine and seek immediate medical attention if you experience symptoms of a severe allergic reaction such as difficulty breathing, swelling of the face or neck, or chest pain.
- This medicine may cause dizziness and fatigue, which can impair your ability to drive or operate machinery.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. For short-term use only. Consider adverse renal effect in chronic kidney disease. Avoid use in moderately severe renal impairment. Increases swelling, worsens renal and heart failure and causes cardiovascular events. Increases risk of bleeding, especially in the gastrointestinal tract. Consider potential interactions especially with preparations that increase risk of bleeding. (updated 16.9.2024)