Daptomycin Accordpharma
Daptomycin Accordpharma is an antibiotic used to treat serious bacterial infections of the skin, blood, and heart in adults and children aged 1-17 years.
Form
injektio-/infuusiokuiva-aine liuosta varten
Strength
500 mg
Active Ingredient
Daptomycin
Manufacturer
Accord Healthcare B.V.
How to Use
Dosage
Your doctor or nurse will determine your dose based on your weight and the type of infection. For skin infections, it's usually 4 mg per kilogram of body weight once daily. For heart or blood infections, it's typically 6 mg per kilogram of body weight once daily. For children (1-17 years), the dose depends on their age and infection type.
Method
This medicine is given directly into a vein (intravenously). For adults, it's given as an infusion over about 30 minutes or as a slow injection over about 2 minutes. For children, it's given as an infusion over 30-60 minutes.
Important
The medicine is usually given once a day. If you have kidney problems, your doctor might give it less often, for example, every other day.
Possible Side Effects
COMMON
- •Fungal infections, such as thrush
- •Urinary tract infections
- •Reduced red blood cell count (anemia)
- •Dizziness
- •Anxiety
- •Sleep difficulties
- •Headache
- •Fever, weakness
- •High or low blood pressure
- •Constipation, abdominal pain
- •Diarrhea, nausea or vomiting
- •Flatulence
- •Abdominal distension or bloating
- •Rashes or itching
- •Pain, itching or redness at the injection site
- •Pain in hands/arms or legs
- •Higher than normal liver enzyme levels or creatine phosphokinase (CPK) in blood tests
RARE
- •Blood disorders (e.g., increased platelets, which may increase blood clotting tendency, or increased white blood cells)
- •Decreased appetite
- •Tingling or numbness in hands or feet, changes in taste
- •Tremor
- •Changes in heart rhythm, flushing
- •Indigestion (dyspepsia), tongue inflammation
- •Itchy skin rash
- •Muscle pain, cramps or weakness, muscle inflammation (myositis), joint pain
- •Kidney disorders
- •Vaginal inflammation or irritation
- •General pain or weakness, fatigue
- •Increased blood sugar, serum creatinine, myoglobin or lactate dehydrogenase levels in blood tests, prolonged blood clotting time or electrolyte imbalance
- •Itchy eyes
- •Yellowing of skin or eyes (jaundice)
- •Prolonged prothrombin time (blood clotting time)
- •Antibiotic-associated colitis (severe or prolonged diarrhea with blood and/or mucus, abdominal pain or fever)
- •Easy bruising, gum bleeding or nosebleeds
Important Warnings
- Do not take this medicine if you are allergic to daptomycin, sodium hydroxide, or any other ingredients listed in section 6.
- Tell your doctor if you have had or have kidney problems. Your doctor might need to change your dose.
- Tell your doctor right away if you feel muscle tenderness, pain, or weakness. You may need blood tests to check your muscles.
- Seek immediate medical help if you get a severe rash, peeling skin, blisters, or sores in your mouth or genitals after taking this medicine. These could be signs of serious skin diseases.
- Tell your doctor immediately if you have signs of a severe allergic reaction, such as wheezing, trouble breathing, swelling of your face, neck, or throat, rash, hives, or fever.
Show 7 more warnings
- Tell your doctor if you experience unusual tingling or numbness in your hands or feet, or if you have difficulty moving. Your doctor will decide if you should continue treatment.
- Tell your doctor if you have diarrhea, especially if it's severe, long-lasting, or contains blood or mucus. This could be a sign of a serious gut infection.
- Tell your doctor if you have fever, worsening cough, or trouble breathing. These could be signs of a rare but serious lung condition called eosinophilic pneumonia.
- Tell your doctor about all other medicines you are taking, especially medicines for cholesterol (statins, fibrates), cyclosporine (for organ transplants or certain skin/joint conditions), pain relievers (NSAIDs, COX-2 inhibitors), or blood thinners (like warfarin). These medicines can interact with Daptomycin Accordpharma.
- This medicine is usually not given during pregnancy. Do not breastfeed while taking this medicine, as it can pass into breast milk and affect your baby.
- This medicine should not be given to children under 1 year old because animal studies have shown it can cause serious side effects in this age group.
- If you are very overweight, your doctor will monitor you closely for side effects, as the medicine levels in your blood might be higher.