Daptomycin Accord Healthcare
This medicine is an antibiotic used to treat serious bacterial infections, such as skin or blood infections, in adults and children over 1 year old.
Form
injektio-/infuusiokuiva-aine liuosta varten
Strength
500 mg
Active Ingredient
Daptomycin
Manufacturer
Accord Healthcare B.V.
How to Use
Dosage
The dose depends on your weight and the type of infection. It's usually 4 mg per kg for skin infections or 6 mg per kg for heart or blood infections.
Method
A doctor or nurse will give it directly into a vein (intravenously). For adults, it's given as an infusion over 30 minutes or an injection over 2 minutes. For children (1-17 years), it's given as an infusion over 30-60 minutes.
Important
This medicine is usually given once a day. If you have kidney problems, the dose might be given less often.
Possible Side Effects
COMMON
- •Fungal infections, such as thrush
- •Urinary tract infections
- •Reduced red blood cells (anemia)
- •Dizziness, anxiety, trouble sleeping
- •Headache
- •Fever, weakness (asthenia)
- •High or low blood pressure
- •Constipation, stomach pain
- •Diarrhea, nausea or vomiting
- •Gas (flatulence)
- •Abdominal swelling or bloating
- •Rash or itching
- •Pain, itching, or redness at the injection site
- •Pain in arms or legs
- •Blood tests showing higher levels of liver enzymes or creatine phosphokinase (CPK)
RARE
- •Blood disorders (e.g., increased platelets or certain white blood cells)
- •Reduced appetite
- •Tingling or numbness in hands or feet, changes in taste
- •Tremors
- •Changes in heart rhythm, flushing
- •Indigestion (dyspepsia), tongue inflammation
- •Itchy skin rash
- •Muscle pain, cramps, weakness, muscle inflammation (myositis), joint pain
- •Kidney problems
- •Vaginal inflammation or irritation
- •General pain or weakness, fatigue
- •Blood tests showing high blood sugar, creatinine, myoglobin, or LDH, prolonged blood clotting time, or electrolyte imbalance
- •Itchy eyes
- •Yellowing of the skin or eyes (jaundice)
- •Prolonged prothrombin time (blood clotting time)
- •Colitis linked to antibiotics (severe or long-lasting diarrhea with blood and/or mucus, stomach pain, or fever)
- •Easy bruising, bleeding gums, or nosebleeds
- •Severe allergic reactions (anaphylaxis, angioedema) with symptoms like chest pain, rash, swelling around the throat, fast or weak pulse, wheezing, fever, chills, hot flashes, dizziness, fainting, metallic taste in mouth.
- •Severe muscle problems (rhabdomyolysis) which can lead to kidney damage
- •Rare, severe lung disease called eosinophilic pneumonia, with symptoms like difficulty breathing, cough, or fever, usually after more than 2 weeks of treatment.
- •Severe skin disorders with symptoms like fever, red raised or fluid-filled spots that can spread, or blisters/sores in the mouth or genital area.
- •Severe kidney problems with symptoms like fever and rash.
Important Warnings
- Do not take if you are allergic to daptomycin or any other ingredients.
- Tell your doctor if you have kidney problems. Your dose might need to be changed.
- Tell your doctor if you experience muscle pain, tenderness, or weakness. You may need blood tests.
- Seek immediate medical help if you get severe skin rashes, peeling skin, blisters, or mouth sores after taking this medicine.
- Tell your doctor right away if you have signs of an allergic reaction like trouble breathing, swelling of your face/throat, rash, hives, or fever.
Show 7 more warnings
- Tell your doctor if you feel unusual tingling, numbness, or weakness in your hands or feet.
- Report severe or long-lasting diarrhea, especially if it contains blood or mucus.
- Tell your doctor if you develop a fever, worsening cough, or trouble breathing, as these could be signs of a rare lung condition.
- This medicine should not be given to children under 1 year old.
- Do not use if you are pregnant or breastfeeding, or if you plan to become pregnant.
- Tell your doctor about all other medicines you are taking, especially statins, fibrates, cyclosporine, NSAIDs, or blood thinners like warfarin.
- Your doctor will take blood tests to check your muscles and other levels regularly during treatment.