Dailiport
Dailiport is an immunosuppressive medicine used to help your body accept a transplanted organ by preventing your immune system from rejecting it.
Form
depotkapseli, kova
Strength
3 mg
Active Ingredient
Tacrolimus monohydrate
Manufacturer
Sandoz A/S
How to Use
Dosage
Your doctor will determine your starting dose based on your body weight, typically 0.10–0.30 mg per kilogram of body weight per day, depending on the transplanted organ.
Method
Take Dailiport orally once daily in the morning, either on an empty stomach or 2–3 hours after a meal. Swallow the capsules whole with a glass of water. Wait at least one hour before your next meal.
Important
The maximum daily dose is determined individually by your doctor.
Possible Side Effects
COMMON
- •Severe stomach pain, possibly with chills, fever, nausea, and vomiting.
- •Transplant organ not working well.
- •Blurred vision.
- •High blood sugar, diabetes, high potassium in blood.
- •Difficulty sleeping.
- •Tremors, headache.
- •High blood pressure.
- •Abnormal liver function tests.
- •Diarrhea, nausea.
- •Kidney problems.
- •Decrease in blood cell counts (platelets, red or white blood cells), increase in white blood cell count, changes in red blood cell count (seen in blood tests).
- •Decreased levels of magnesium, phosphate, potassium, calcium, or sodium in the blood; fluid overload; increased uric acid or fat levels in the blood; decreased appetite; increased acidity in the blood; other changes in blood salt levels (seen in blood tests).
- •Anxiety, confusion and disorientation, depression, mood changes, nightmares, hallucinations, mental disorders.
- •Seizures, altered consciousness, tingling or numbness (sometimes painful) in hands and feet, dizziness, impaired handwriting, nervous system disorders.
- •Blurred vision, increased light sensitivity, eye symptoms.
- •Ringing in the ears.
- •Reduced blood flow in heart vessels, fast heartbeat.
- •Bleeding, partial or complete blockage of blood vessels, decreased blood pressure.
- •Shortness of breath, changes in lung tissue, fluid accumulation around lungs, pharyngitis, cough, flu-like symptoms.
- •Stomach problems like inflammation and ulcers causing stomach pain and diarrhea, stomach bleeding, inflammation or ulcers in mouth, fluid accumulation in abdomen, vomiting, abdominal pain, indigestion, constipation, gas, swelling, loose stools.
- •Gallbladder problems, yellow skin due to liver disorders, liver tissue damage and liver inflammation.
- •Itching, rash, hair loss, acne, increased sweating.
- •Joint, limb, back and foot pain, muscle cramps.
- •Kidney failure, decreased urine output, difficulty or pain when urinating.
- •General weakness, fever, fluid retention, pain and discomfort, increased alkaline phosphatase levels in blood, weight gain, abnormal body temperature sensation.
RARE
- •Damage to small blood vessels (thrombotic microangiopathy), including hemolytic-uremic syndrome, with symptoms like low or no urine output, extreme tiredness, yellowing skin/eyes, unusual bruising or bleeding, and signs of infection.
- •Damage to small blood vessels (thrombotic thrombocytopenic purpura), characterized by fever, pin-prick size red/purple spots under the skin, unexplained severe tiredness, confusion, yellowing skin/eyes, symptoms of acute kidney failure (low/no urine output), vision loss, and seizures.
- •Severe skin reaction (toxic epidermal necrolysis), with skin/mucous membrane erosion and blistering, red swollen skin that may peel off widely.
- •Blindness.
- •Severe skin reaction (Stevens-Johnson syndrome), with widespread skin pain, facial swelling, severe blistering of skin, mouth, eyes, and genitals, hives, tongue swelling, spreading red or purplish rash, skin peeling.
- •Changes in heart rate (Torsades de Pointes), possibly with chest pain, fainting, dizziness, nausea, palpitations, and difficulty breathing.
- •Opportunistic infections (caused by bacteria, fungi, viruses, and protozoa): prolonged diarrhea, fever, and sore throat.
- •Benign and malignant tumors, including skin cancers and Kaposi's sarcoma (a rare cancer with skin lesions/ulcers, changes in skin color/shape, or lumps).
- •Severe decrease in red blood cells (pure red cell aplasia), decrease in red blood cells due to abnormal breakdown (hemolytic anemia) with tiredness, and decrease in infection-fighting white blood cells with fever (febrile neutropenia).
- •Changes in blood clotting values, decrease in all blood cell counts (seen in blood tests).
- •Dehydration, inability to urinate.
- •Abnormal blood test results: decreased protein or sugar, increased phosphate, increased lactate dehydrogenase enzyme.
- •Deep unconsciousness (coma), brain hemorrhage, stroke, paralysis, brain activity disorders, speech and language disorders, memory problems.
- •Clouding of eye lens, hearing impairment.
- •Heart rhythm disorders, cardiac arrest, weakened heart function, heart muscle disease, enlarged heart muscle, increased heart rate, abnormal ECG, abnormal heart rate/pulse.
- •Blood clot in a limb blood vessel, shock.
- •Difficulty breathing, respiratory diseases, asthma.
- •Bowel obstruction, increased amylase levels in blood, stomach contents flowing back into esophagus (reflux), delayed stomach emptying.
- •Skin inflammation, burning sensation on skin in sunlight.
- •Joint problems.
- •Painful periods and menstrual disorders.
- •Multiple organ dysfunction, flu-like symptoms, increased sensitivity to heat and cold, chest pressure, nervousness or unusual feeling, weight loss.
- •Small bleedings under the skin.
- •Increased muscle tension.
- •Deafness.
- •Fluid accumulation around the heart.
- •Acute shortness of breath.
- •Cyst formation in the pancreas.
- •Liver circulation disorders.
- •Severe illness with blisters on skin, mouth, eyes, and genitals, increased hair growth.
- •Thirst, falls, chest tightness, reduced mobility, ulcers.
- •Muscle weakness.
- •Abnormal findings in heart ultrasound.
- •Liver failure.
- •Painful urination with blood in urine.
- •Increased fat tissue.
Important Warnings
- Do not take Dailiport if you are allergic to tacrolimus, sirolimus, certain antibiotics (macrolides), peanuts, or soy.
- Dailiport capsules release medicine slowly. Do not swap Dailiport with other tacrolimus capsules that release medicine immediately.
- Avoid St. John's Wort and other herbal remedies as they can affect Dailiport's effectiveness.
- Tell your doctor immediately if you have vision problems, such as blurred vision, changes in color vision, difficulty seeing clearly, or a narrowed vision field.
- Avoid sunlight and UV radiation while taking Dailiport, as it can increase the risk of skin cancer. Use protective clothing and high-SPF sunscreen.
Show 5 more warnings
- Do not eat grapefruit or drink grapefruit juice while taking Dailiport, as it can affect the medicine's levels in your blood.
- Do not breastfeed while taking Dailiport, as the medicine passes into breast milk.
- Do not drive or operate machinery if you feel dizzy, drowsy, or have vision problems after taking Dailiport. These effects are more common with alcohol.
- Inform any doctor you visit that you are taking Dailiport, as other medicines can affect its levels in your blood.
- Dailiport is not recommended for children and adolescents under 18 years of age.