Dacarbazine medac
Dacarbazine belongs to a group of chemotherapy drugs that affects the growth of cancer cells and is used to treat various cancers.
Form
injektio/infuusiokuiva-aine, liuosta varten
Strength
200 mg
Active Ingredient
Dacarbazine
Manufacturer
Medac Gesellschaft Für Klinische Spezialpräparate mbH
How to Use
Dosage
A typical dose for skin cancer is 200–250 mg per square meter (m²) of body surface area once daily for five consecutive days every three weeks.
Method
The medication is given intravenously either as a fast injection into a vein or a slow infusion into a vein, lasting 15–30 minutes.
Important
The maximum single daily dose is 250 mg per square meter (m²) of body surface area.
Possible Side Effects
COMMON
- •Decreased blood cell counts (red, white blood cells, and/or platelets), which can make you tired, more prone to infections, or bruise easily.
- •Loss of appetite, feeling sick (nausea), and throwing up (vomiting), which can be severe.
RARE
- •Hair loss.
- •Skin getting darker or more sensitive to sunlight.
- •Flu-like symptoms (feeling tired, chills, fever, muscle pain) or infections.
- •Very low counts of all blood cells or specific white blood cells (granulocytes).
- •Severe allergic reaction with symptoms like low blood pressure, swelling (hands, feet, face, lips, throat), fast pulse, hives, itching, or red skin.
- •Headache, blurred vision, confusion, drowsiness, or seizures.
- •Numbness, tingling, or redness in your face after the injection.
- •Diarrhea.
- •Liver problems (shown by high liver enzyme levels, yellow skin or eyes, or severe damage to liver blood vessels or cells).
- •Kidney problems.
- •Skin rashes (redness, spots, hives) or irritation at the injection site.
Important Warnings
- Do not use this medicine if you are allergic to dacarbazine or any other ingredient.
- If you have too few white blood cells and/or platelets in your blood.
- If you have severe liver or kidney disease.
- If you are pregnant or breastfeeding.
- Do not take yellow fever vaccine or live vaccines during this treatment.
Show 2 more warnings
- Tell your doctor about all other medicines you are taking, as they may affect how this medicine works.
- Avoid alcohol and discuss eating just before a dose with your doctor to help reduce nausea.