Dabigatran etexilate Krka
This medicine helps prevent blood clots by stopping a substance in your body that forms them.
How to Use
Dosage
Adults typically take 220 mg once daily for clot prevention after surgery, or 300 mg twice daily for stroke prevention and treating existing clots; doses vary based on age, kidney function, and other medications. Children 8 years and older take doses based on weight and age, twice daily.
Method
Swallow the capsule whole with a glass of water, with or without food. Do not break, chew, or open the capsule, as this increases the risk of bleeding.
The maximum daily dose for adults is 600 mg (taken as 300 mg twice a day). For some conditions, it can be 220 mg once daily. For children, the maximum daily dose is determined by their weight and age, up to 600 mg.
Possible Side Effects
- •Low hemoglobin (a substance in red blood cells)
- •Abnormal liver test results
- •Bleeding (e.g., nosebleeds, in stool or urine, from genitals or rectum, under skin)
- •Stomach or belly pain
- •Indigestion
- •Loose stools, diarrhea
- •Feeling sick (nausea)
- •Vomiting
- •Acid reflux (heartburn)
- •Hair loss
- •Low red blood cell count
- •Low platelet count
- •Allergic skin rash (itchy, red bumps) or sudden skin changes
- •Bruises or blood clots forming under the skin
- •Bleeding (e.g., in the brain, joints, surgical cuts, injection sites, or from injury)
- •Bloody fluid from where a tube connects to a vein
- •Coughing up blood or bloody mucus
- •General allergic reaction
- •Itching
- •Stomach or gut ulcers (including in the food pipe)
- •Inflammation of the food pipe or stomach
- •Trouble swallowing
- •Fluid leaking from a wound
- •High liver enzyme levels
- •Yellow skin or eyes (jaundice)
- •Severe allergic reaction with trouble breathing, dizziness, or swelling of face/throat
- •Wheezing or trouble breathing
- •Low white blood cell count (cells that fight infection) or no white blood cells
- •Blood in stool found in lab tests
- •Low overall blood cell count
Important Warnings
- Do not take this medicine if you are allergic to dabigatran etexilate or any other ingredient in this medicine.
- Do not take this medicine if you have severe kidney problems.
- Do not take this medicine if you are currently bleeding.
- Do not take this medicine if you have organ damage that increases the risk of serious bleeding (e.g., stomach ulcer, brain injury or bleeding, or recent brain or eye surgery).
- Do not take this medicine with other blood thinners (like warfarin, rivaroxaban, apixaban, or heparin), unless your doctor specifically instructs you during a treatment switch or for certain procedures.
Show 17 more warnings
- Do not take this medicine if you have an artificial heart valve that requires permanent blood-thinning treatment.
- Do not take this medicine if you are pregnant or breastfeeding, unless your doctor says it's safe. If you can become pregnant, you should avoid getting pregnant while taking this medicine.
- Tell your doctor if you have a higher tendency to bleed, which can be natural, from an unknown cause, or due to other medicines.
- Tell your doctor if you have severe liver problems or a liver disease that could be life-threatening.
- Tell your doctor if you are taking certain other medicines, including some antifungals, medicines for organ transplants, some heart rhythm medicines, or medicines for hepatitis C.
- Tell your doctor if you have had recent bleeding, a biopsy, or a serious injury.
- Tell your doctor if you have inflammation of the stomach or esophagus, or heartburn.
- Tell your doctor if you are taking NSAIDs (e.g., ibuprofen, diclofenac).
- Tell your doctor if you have a heart infection.
- Tell your doctor if you have signs of dehydration, such as feeling thirsty, reduced urination, or dark/foamy urine.
- Tell your doctor if you are over 75 years old or an adult weighing 50 kg or less.
- For children, tell your doctor if the child has an infection around or in the brain.
- Tell your doctor if you have had a heart attack or have a condition that increases your risk of a heart attack.
- Tell your doctor if you have liver disease with abnormal blood test results.
- If you need surgery or a spinal procedure, your doctor might temporarily stop this medicine. It is very important to follow their instructions carefully about when to take it before and after.
- Contact your doctor immediately if you fall or injure yourself during treatment, especially if you hit your head, as there might be a risk of bleeding.
- Tell your doctor if you have antiphospholipid syndrome (an immune system disorder that increases blood clot risk), as your treatment might need to be adjusted.
Use in Elderly Patients
Suitable for older adults, with specific precautions. Consider renal impairment, age and body weight when determining the dosage. Consider potential interactions especially with other drugs that increase the risk of bleeding. (updated 19.9.2025)