Coversyl Comp Novum
Coversyl Comp Novum is a medicine combining two ingredients, perindopril and indapamide, to lower high blood pressure in adults.
Form
tabletti, kalvopäällysteinen
Strength
5 mg / 1.25 mg
Active Ingredient
Perindopril arginine
Manufacturer
Les Laboratoires Servier
How to Use
Dosage
One tablet daily.
Method
Take in the morning before a meal, swallow with water.
Important
One tablet.
Possible Side Effects
COMMON
- •Low potassium levels in your blood.
- •Skin reactions (like rashes) for people prone to allergies or asthma.
- •Headache.
- •Dizziness.
- •Feeling of spinning (vertigo).
- •Tingling sensation.
- •Trouble seeing.
- •Ringing in the ears (tinnitus).
- •Cough.
- •Shortness of breath.
- •Stomach problems like feeling sick, throwing up, stomach ache, changes in taste, indigestion, diarrhea, or constipation.
- •Allergic skin reactions (like rash or itching).
- •Muscle cramps.
- •Feeling tired.
RARE
- •Changes in mood.
- •Feeling sad (depression).
- •Trouble sleeping.
- •Hives (itchy red welts).
- •Red spots on the skin (purpura).
- •Skin blisters.
- •Kidney problems.
- •Trouble getting or keeping an erection (impotence).
- •Sweating a lot.
- •More of a certain type of white blood cell (eosinophils).
- •Changes in blood test results: high potassium (goes back to normal when medicine is stopped), low sodium (can cause dehydration and low blood pressure).
- •Feeling sleepy.
- •Fainting.
- •Feeling your heart beat strongly or quickly (palpitations).
- •Fast heartbeat (tachycardia).
- •Very low blood sugar in people with diabetes.
- •Inflammation of blood vessels (vasculitis).
- •Dry mouth.
- •Skin being extra sensitive to sunlight (photosensitivity).
- •Joint pain.
- •Muscle pain.
- •Chest pain.
- •Generally feeling unwell.
- •Swelling in your arms or legs.
- •Fever.
- •Increased levels of urea and creatinine in your blood (shown in blood tests).
- •Falls.
- •Worsening of a skin condition called psoriasis.
- •Changes in blood test results: low chloride, low magnesium, increased liver enzymes, high bilirubin.
- •Flushing (redness of the face).
- •Less or no urine, or sudden kidney failure.
- •Dark urine, feeling or being sick, muscle cramps, confusion, and fits (seizures). These can be signs of SIADH (a problem with a hormone that controls body water).
- •Feeling confused.
- •A rare type of lung inflammation (eosinophilic pneumonia).
- •Blocked or runny nose (rhinitis).
- •Severe kidney problems.
- •Changes in blood tests, like fewer white or red blood cells, lower hemoglobin, or fewer platelets.
- •High calcium levels in your blood.
- •Liver not working normally.
- •Abnormal heart rhythm shown on an ECG.
- •Changes in blood tests: high uric acid and high blood sugar levels.
- •Nearsightedness (myopia).
- •Blurred vision, worse eyesight, or eye pain due to high pressure in the eye (signs of fluid buildup in the eye or a type of glaucoma).
- •Fingers or toes changing color, feeling numb, or painful (Raynaud's phenomenon).
- •Worsening of systemic lupus erythematosus (a disease affecting connective tissue).
Important Warnings
- Do not take if you are allergic to perindopril, indapamide, other similar blood pressure medicines (ACE inhibitors), sulfa medicines, or any other ingredient in this medicine.
- Do not take if you or a family member has ever had a severe allergic reaction with swelling of the face, tongue, or throat (angioedema), especially after taking an ACE inhibitor.
- Do not take if you have diabetes or kidney problems and are taking a blood pressure medicine called aliskiren.
- Do not take if you have severe liver disease or a brain problem caused by liver disease (hepatic encephalopathy).
- Do not take if you have severe kidney disease with blocked blood flow to your kidneys, or if you are on dialysis or other blood filtering treatment.
Show 15 more warnings
- Do not take if you have low potassium levels in your blood.
- Do not take if you have untreated heart failure with severe fluid buildup and breathing problems.
- Do not take if you are more than 3 months pregnant (it's also best to avoid in early pregnancy).
- Do not take if you are taking or have recently taken a medicine for heart failure that contains sacubitril and valsartan, as this can increase the risk of angioedema.
- Stop taking and see a doctor right away if you get very dizzy or faint due to very low blood pressure.
- Stop taking and see a doctor right away if you have chest tightness, wheezing, or difficulty breathing (bronchospasm).
- Stop taking and see a doctor right away if your face, lips, mouth, tongue, or throat swell, causing trouble breathing (angioedema).
- Stop taking and see a doctor right away if you have severe skin reactions like a rash with red itchy patches, widespread rash, hives, severe itching, blistering, peeling skin, or mouth sores (Stevens-Johnson syndrome), or other severe allergic reactions.
- Stop taking and see a doctor right away if you have heart or blood vessel problems like an irregular heartbeat, chest pain during effort (angina pectoris), or a heart attack.
- Stop taking and see a doctor right away if you have weakness in your arms or legs, or speech problems, as these could be signs of a stroke.
- Stop taking and see a doctor right away if you have severe stomach and back pain, and feel very sick (pancreatitis).
- Stop taking and see a doctor right away if your skin or eyes turn yellow (jaundice), which can be a sign of liver inflammation.
- Stop taking and see a doctor right away if you have a life-threatening irregular heartbeat.
- Stop taking and see a doctor right away if you have a brain problem caused by liver disease (hepatic encephalopathy).
- Stop taking and see a doctor right away if you have muscle weakness, cramps, tenderness, or pain, especially if you also feel unwell or have a fever, as these may be signs of abnormal muscle breakdown.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Effectiveness is reduced in renal impairment. Consider risk of orthostatic hypotension and hyponatraemia and -kalemia. (updated 19.5.2025)