Coprenessa
Coprenessa is a combination medicine with two active ingredients, perindopril and indapamide, both of which lower blood pressure and together help control your high blood pressure.
Form
tabletti
Strength
8 mg / 2.5 mg
Active Ingredient
Perindopril tert-butylamine
Manufacturer
KRKA d.d. Novo mesto
How to Use
Dosage
The recommended dose is one tablet once a day.
Method
Take the tablet preferably in the morning before a meal, swallowed with a glass of water.
Important
Do not exceed one tablet per day.
Possible Side Effects
COMMON
- •Severe dizziness or fainting due to low blood pressure
- •Headache
- •Dizziness
- •Weakness or tiredness
- •Vision problems
- •Ringing in the ears (tinnitus)
- •Tingling or numbness
- •Shortness of breath or cough
- •Nausea and vomiting
- •Stomach pain
- •Taste disturbances
- •Indigestion, diarrhea, or constipation
- •Muscle cramps
- •Allergic skin reactions (e.g., rash, itching)
- •Low potassium in the blood
RARE
- •Chest tightness, wheezing, and shortness of breath (bronchospasm)
- •Swelling of the face, lips, mouth, tongue or throat, making it hard to breathe (angioedema)
- •Severe skin reactions, such as widespread rash, hives, blistering, or peeling
- •Heart problems (e.g., irregular heartbeat, chest pain, heart attack)
- •Weakness in arms or legs, or speech problems, which may indicate a stroke
- •Pancreatitis (severe stomach and back pain, feeling very unwell)
- •Yellowing of the skin or eyes (jaundice), a sign of liver inflammation
- •Life-threatening irregular heartbeat
- •Brain disease caused by liver problems (hepatic encephalopathy)
- •Muscle weakness, cramps, tenderness, or pain, especially with fever or general unwellness
- •Mood changes, sleep problems, depression, or confusion
- •Excessive sweating or impotence
- •Drowsiness or fainting
- •Very low blood sugar (for diabetic patients)
- •Inflammation of blood vessels (vasculitis) or dry mouth
- •Increased sensitivity to sunlight
- •Joint pain, muscle pain, chest pain, general discomfort, or fever
- •Falls
- •Worsening of psoriasis
- •Dark urine, nausea, vomiting, muscle cramps, confusion, and seizures (signs of SIADH)
- •Reduced or no urine output
- •Flushing
- •Acute kidney failure
- •Stuffy or runny nose (rhinitis)
- •Eosinophilic pneumonia (a rare lung inflammation)
- •Changes in blood cell counts (e.g., low white or red blood cells, low hemoglobin, platelets)
- •High calcium in the blood or abnormal liver function
- •Abnormal ECG results
- •Changes in lab values (e.g., high uric acid or high blood sugar)
- •Eye problems (e.g., blurred vision, eye pain due to high pressure/fluid buildup)
- •Worsening of lupus erythematosus (a connective tissue disease)
- •Discoloration, numbness, and pain in fingers or toes (Raynaud's phenomenon)
Important Warnings
- Do not take if you are allergic to perindopril, indapamide, other ACE inhibitors, sulfonamides, or any other ingredient in this medicine.
- Do not take if you or a family member have had a severe allergic reaction with swelling of the face, tongue, or throat (angioedema) during previous ACE inhibitor treatment.
- Do not take if you have severe liver or kidney disease or are on dialysis.
- Do not use if you are more than 3 months pregnant. It is also advised to avoid it during early pregnancy.
- Do not take if you have diabetes or kidney problems and are taking aliskiren for high blood pressure.
Show 2 more warnings
- Do not take if you are taking or have recently taken sacubitril/valsartan (for heart failure).
- Talk to your doctor before taking this medicine if you have heart failure, other heart problems, kidney problems, or liver disease.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Effectiveness is reduced in renal impairment. Consider risk of orthostatic hypotension and hyponatraemia and -kalemia. (updated 19.5.2025)