Coprenessa
This medicine treats high blood pressure in patients whose blood pressure was not controlled enough by perindopril alone.
Form
tabletti
Strength
4 mg / 1.25 mg
Active Ingredient
Perindopril tert-butylamine
Manufacturer
KRKA d.d. Novo mesto
How to Use
Dosage
The usual dose is one tablet daily.
Method
Take the tablet whole with a glass of water, preferably in the morning before a meal.
Important
Your doctor will determine your maximum daily dose, especially if you have kidney disease.
Possible Side Effects
COMMON
- •Headache, dizziness, spinning sensation (vertigo), tingling or numbness in hands/feet.
- •Changes in vision, ringing in the ears.
- •Cough, feeling short of breath.
- •Upset stomach, nausea, vomiting, stomach pain, taste changes, indigestion, diarrhea, constipation.
- •Muscle cramps.
- •Skin rashes, itching, feeling tired.
- •Low potassium levels in the blood.
RARE
- •Feeling down or anxious, trouble sleeping.
- •Skin rashes, hives, increased sweating, or skin being very sensitive to the sun.
- •Problems with erections (impotence).
- •Changes in blood tests (like potassium, sodium, blood sugar, liver tests).
- •Fast or irregular heartbeats.
- •Dry mouth.
- •Joint or muscle pain, chest pain, general unwell feeling, swelling in your arms or legs, fever, or falling.
- •Dark urine, confusion, muscle cramps, or seizures.
- •Sudden kidney problems or less urine than usual.
- •Blurred vision, worsening eyesight, or eye pain caused by high pressure inside the eye.
- •Worsening of a disease called lupus.
- •Fingers or toes changing color, feeling numb, or painful (Raynaud's phenomenon).
Important Warnings
- Do not take this medicine if you are allergic to perindopril, any other ACE inhibitor, indapamide, other sulfonamides, or any other ingredient in this medicine.
- Do not take if you have ever had severe swelling of the face, tongue, or throat (angioedema) after taking an ACE inhibitor, or if this condition runs in your family.
- Do not take if you have severe liver disease or a brain disease caused by liver problems (hepatic encephalopathy).
- Do not take if you have severe kidney disease or are on dialysis.
- Do not take if you have very low or very high potassium levels in your blood.
Show 4 more warnings
- Do not take if you have untreated or uncontrolled heart failure, especially if you have severe fluid build-up or breathing problems.
- Do not take if you are more than 3 months pregnant. Avoid also during early pregnancy.
- Do not take if you have diabetes or kidney problems and are taking a blood pressure medicine containing aliskiren.
- Do not take if you are taking or have recently taken sacubitril/valsartan for chronic heart failure, as it increases the risk of angioedema.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Effectiveness is reduced in renal impairment. Consider risk of orthostatic hypotension and hyponatraemia and -kalemia. (updated 19.5.2025)