Comboval
This medicine contains paracetamol and ibuprofen, which work together to relieve sudden, moderate pain when given into a vein.
Form
infuusioneste, liuos
Strength
10 mg/ml + 3 mg/ml
Active Ingredient
Paracetamol
Manufacturer
Laboratoire Aguettant
How to Use
Dosage
For adults over 50 kg, the typical dose is one vial every 6 hours as needed.
Method
A healthcare professional will give you this medicine as an infusion into a vein over 15 minutes.
Important
Do not use more than four vials (4000 mg paracetamol and 1200 mg ibuprofen) in 24 hours. Do not use for more than 2 days.
Possible Side Effects
COMMON
- •Feeling sick or throwing up.
- •Not wanting to eat.
- •Heartburn or pain in the upper stomach.
- •Stomach cramps, gas, constipation, diarrhea, or a small amount of bleeding from the stomach or intestines.
- •Skin rashes or itching.
- •Headache.
- •Feeling dizzy.
- •Feeling nervous.
- •Ringing or buzzing sound in the ears.
- •Gaining weight, swelling, or fluid buildup in your body, especially in your ankles or legs.
RARE
- •Throwing up blood or a substance that looks like coffee grounds.
- •Bleeding from the bottom, black or sticky stools, or bloody diarrhea.
- •Swelling of your face, lips, or tongue, which can make it hard to swallow or breathe.
- •Asthma, wheezing (a whistling sound when breathing), or trouble breathing.
- •Sudden or bad itching, skin rash, or hives.
- •Severe blistering rash and bleeding around your lips, eyes, mouth, nose, and genitals (Stevens-Johnson syndrome).
- •Worsening of severe skin infections (rash, blisters, skin color changes, fever, sleepiness, diarrhea, nausea) or other infections like chickenpox or shingles, or a severe infection with skin and muscle tissue death and peeling skin.
- •Fever, feeling generally unwell, feeling sick, stomach pain, headache, and stiff neck (signs of aseptic meningitis, which is brain swelling).
- •A severe skin reaction called DRESS syndrome (rash, fever, swollen glands, and an increase in certain white blood cells).
- •A widespread red, peeling rash with bumps under the skin and blisters, mainly in skin folds, on the body and arms, with fever at the start of treatment (acute generalized exanthematous pustulosis).
- •A serious condition where the blood becomes too acidic (metabolic acidosis) in severely ill patients using paracetamol.
- •Fewer red blood cells, nosebleeds, and heavier menstrual periods.
- •Allergic reactions: skin rash, tiredness, joint pain (e.g., serum sickness, lupus, certain blood vessel inflammation, angioedema).
- •Breast enlargement in men or low blood sugar.
- •Trouble sleeping.
- •Mood changes, like feeling sad, confused, or nervous.
- •Eye problems, such as blurry vision (which can get better), sore or red eyes, or itchy eyes.
- •Thick mucus.
- •Severe stomach pain or tenderness, or stomach/intestinal ulcers.
- •Worsening of gut inflammation (colitis) and bowel inflammation (Crohn's disease), and complications like diverticulitis (a burst ulcer or fistula).
- •Not being able to fully empty your bladder (urinary retention).
- •Abnormal results in blood, liver, and kidney tests.
- •Tingling in your hands and feet.
- •Strange dreams, or seeing things that are not real (hallucinations).
- •Kidney damage (especially with long-term use).
- •High levels of uric acid in your blood.
- •Low potassium levels: feeling weak, tired, or having muscle cramps.
- •Signs of anemia, such as feeling tired, headaches, shortness of breath, and pale skin.
- •Bleeding or bruising that happens more easily than usual, red or purple spots under the skin.
- •Severe or lasting headache.
- •A feeling of spinning (vertigo).
- •Fast or irregular heartbeats.
- •High blood pressure and possible heart problems.
- •Inflammation of the food pipe (esophagus).
- •Yellowing of the skin and/or eyes (jaundice).
- •Liver damage (especially with long-term use).
- •Hair loss.
- •Increased sweating.
- •Signs of frequent or severe infections, like fever, bad chills, sore throat, or mouth sores.
- •Kidney problems in different forms, including kidney inflammation, kidney disease with swelling, and sudden or long-term kidney failure.
Important Warnings
- Do not use this medicine if you are allergic to paracetamol, ibuprofen, other anti-inflammatory medicines (NSAIDs), or any other ingredient.
- Do not use if you have severe heart, liver, or kidney problems.
- Do not use if you drink a lot of alcohol regularly.
- Do not use if you have had asthma, hives, or allergic reactions to aspirin or other anti-inflammatory medicines.
- Do not use if you have had stomach bleeding or a hole in your stomach or intestine from previous anti-inflammatory medicine use.
Show 10 more warnings
- Do not use if you have or have had a stomach ulcer or bleeding in your stomach or intestine (at least two separate events).
- Do not use if you have bleeding in your brain or any other active bleeding.
- Do not use if you have a blood clotting disorder or a tendency to bleed easily.
- Do not use if you are severely dehydrated (due to throwing up, diarrhea, or not drinking enough fluids).
- Do not use during the last three months of pregnancy, as it can harm your unborn baby or cause problems during birth.
- This medicine is not for people under 18 years old.
- Always check that other medicines you take do not contain paracetamol or ibuprofen to avoid overdose. Do not use more than the recommended amount.
- Do not drink alcohol while using this medicine, as it can cause liver damage.
- This medicine may make it harder for women to get pregnant and is not recommended if you are trying to have a baby.
- If you feel dizzy, sleepy, tired, or have vision problems, do not drive or use machines.
Use in Elderly Patients
Category A
Suitable for older adults. . Can be used concurrently with warfarin only if INR values are monitored. Consider paracetamol in OTC drugs and combination products. . (updated 14.4.2025)