Clindamycin Navamedic
Clindamycin Navamedic is an antibiotic used to treat various serious bacterial infections.
Form
infuusioneste, liuos
Strength
600 mg
Active Ingredient
Clindamycin phosphate
Manufacturer
Navamedic ASA
How to Use
Dosage
For severe infections: 1800-2700 mg daily, divided into 2 or 3 equal doses. For less severe infections: 1200-1800 mg daily, divided into 2, 3, or 4 equal doses. The doctor will decide your exact dose.
Method
This medicine is given as a drip into a vein by a doctor or nurse. Each infusion takes 10-60 minutes.
Important
The maximum daily dose is 2700 mg for adults and adolescents over 12 years old.
Possible Side Effects
COMMON
- •Stomach or gut problems like nausea, stomach pain, vomiting, and diarrhea.
- •Severe, long-lasting, or bloody diarrhea during or after treatment, which can be a sign of gut inflammation.
- •Changes in blood counts, such as fewer white blood cells (increasing infection risk), fewer platelets (increasing bleeding/bruising risk), increased eosinophils, or fewer granulocytes.
- •Vein inflammation (thrombophlebitis).
- •Abdominal pain, inflammation of the esophagus, or inflammation of the mouth lining.
- •Skin changes like widespread rash with blisters (maculopapular exanthem, measles-like rash), and hives.
- •Changes in liver function test results and increased liver enzyme levels.
RARE
- •Reduced number of certain white blood cells (granulocytopenia), which increases infection risk.
- •Nervous system disorders, such as blocked nerve signals (neuromuscular blockade) and taste disturbances (dysgeusia).
- •Heart and breathing arrest, and low blood pressure if the medicine is given too quickly (clindamycin should only be given as an infusion, not an injection into a vein).
- •Low blood pressure.
- •Rash with irregular red patches (erythema multiforme), itchy skin.
- •Pain and abscess at the injection site.
- •Sudden swelling of the skin and mucous membranes (e.g., throat or tongue), causing breathing difficulties and/or itching and rash (angioedema), joint swelling.
- •Drug fever.
- •Severe skin reactions: widespread rash with blisters and peeling skin, especially around the mouth, nose, eyes, and genitals (Stevens-Johnson syndrome), and a more severe blistering skin disease (toxic epidermal necrolysis or Lyell's syndrome).
- •Widespread, red rash with peeling skin (exfoliative dermatitis, bullous dermatitis).
- •Severe allergic reaction causing swelling of the face or throat (angioedema).
- •Inflammation of the vaginal lining (vaginitis).
- •Severe acute allergic reaction (anafylactic reaction).
- •Liver inflammation (hepatitis) with yellowing of the skin and whites of the eyes (jaundice).
- •Allergic reaction with rash and blisters.
- •Joint pain or tenderness (polyarthritis).
- •Colon inflammation caused by Clostridium difficile infection.
- •Vaginal infection.
- •Severe acute allergic reaction, including significant drop in blood pressure, paleness, increased heart rate, clammy skin, reduced consciousness (anaphylactic shock, anaphylactoid reaction, hypersensitivity).
- •Disturbance of the sense of smell.
- •Drowsiness.
- •Dizziness.
- •Headache.
- •Jaundice.
- •Fever, swollen lymph nodes, or rash (DRESS syndrome), which can be severe and life-threatening.
- •Rare rash with sudden onset of red skin and small pus-filled blisters (acute generalized exanthematous pustulosis, AGEP).
- •Irritation at the injection site.
- •Swelling of legs, ankles, or feet due to fluid retention, shortness of breath, or nausea.
Important Warnings
- Do not use if you are allergic to clindamycin, lincomycin, or any other ingredients in this medicine.
- Tell your doctor if you have liver or kidney problems.
- Tell your doctor if you have muscle problems like myasthenia gravis or Parkinson's disease.
- Tell your doctor if you have a history of bowel problems (e.g., colon inflammation).
- Tell your doctor about any allergies, especially to penicillin, as some people allergic to penicillin can also be allergic to clindamycin.
Show 4 more warnings
- This medicine can cause serious skin and allergic reactions. Seek immediate medical help if you develop severe skin rash, blistering, peeling skin, high fever, joint pain, or eye inflammation.
- This medicine can cause severe gut infection (colitis) leading to severe or bloody diarrhea. Tell your doctor immediately if you get diarrhea during or after treatment.
- This medicine should not be given to children under 12 years old.
- Contact your doctor immediately if you notice less urine, swelling in your legs/ankles/feet, shortness of breath, or nausea, as these can be signs of acute kidney injury.
Use in Elderly Patients
Category A
Suitable for older adults. Bear in mind the risk of pseudomembranous colitis. (updated 4.12.2023)