Cisplatin Accord
Cisplatin Accord contains cisplatin, a cancer medicine used to destroy certain cancer cells in the body, such as testicular, ovarian, and lung cancer.
Form
infuusiokonsentraatti, liuosta varten
Strength
1 mg/ml
Active Ingredient
Cisplatin
Manufacturer
Accord Healthcare B.V.
How to Use
Dosage
Your doctor will decide your exact dose and how often you get it. Typically, a dose is 50-120 mg per square meter of body surface (mg/m²) every 3-4 weeks, or 15-20 mg/m² daily for five days every 3-4 weeks.
Method
This medicine is given as a drip directly into a vein (infusion) over 6-8 hours by a specialist.
Important
The maximum daily dose is typically 15-20 mg per square meter of body surface.
Possible Side Effects
COMMON
- •Reduced bone marrow function (fewer blood cells), which can increase the risk of infection, bruising, and bleeding, and cause weakness.
- •Decreased sodium levels in the blood.
- •Fever.
- •Severe pain or swelling in a leg, chest pain, or breathing difficulties (may be a sign of a blood clot).
- •Fast, irregular, or slow heartbeat.
- •Sepsis (blood poisoning).
RARE
- •Hearing problems or ringing in the ears (tinnitus).
- •Decreased magnesium levels in the blood.
- •Abnormal sperm production.
- •Increased risk of acute leukemia.
- •Seizures or fainting.
- •Headache, confusion, vision loss, or other brain function problems (like speech difficulties, memory loss, paralysis).
- •Heart attack or cardiac arrest.
- •Inflammation of the mouth lining.
- •Nerve damage (tingling, itching, numbness, loss of taste/touch/vision, sudden sharp pain).
- •Infection symptoms (such as sore throat).
- •Anemia where red blood cells are destroyed too quickly (hemolytic anemia).
- •Problems with a hormone that regulates fluid and salt balance, which can cause swelling or low blood sodium.
- •Dehydration.
- •Decreased blood calcium, phosphate, or potassium levels.
- •Increased blood uric acid.
- •Muscle cramps or electric shock-like sensations in the limbs.
- •Loss of taste, vision problems (such as blurred vision, strange colors, eye pain), or other heart problems.
- •Unusually cold or pale hands and feet.
- •Tingling, numbness, or tremors in the hands, feet, arms, or legs.
- •Persistent headache, nausea, vomiting, loss of appetite, hiccups, or diarrhea.
- •Increased liver enzymes or bilirubin.
- •Breathing difficulties, shortness of breath, chest pain when breathing, or coughing up blood.
- •Kidney or urinary problems.
- •Hair loss, rash, extreme fatigue, or weakness.
- •Swelling or tenderness at the injection site.
- •Convulsions and twitching.
- •Burning or tingling sensation.
- •Unexpected bruising or bleeding.
- •Hemolytic-uremic syndrome (changes in kidneys and blood).
Important Warnings
- Do not use if you are allergic to cisplatin or other platinum-containing medicines, or any other ingredient in this medicine.
- Do not use if you have a low blood cell count, are breastfeeding, or have severe kidney disease, hearing problems, or are dehydrated.
- Talk to your doctor if you have symptoms of nerve damage (like tingling or numbness) or have received radiation therapy to the head.
- Avoid the yellow fever vaccine and discuss other vaccinations with your doctor, as some live vaccines can cause serious infections.
- Remember to drink plenty of water after treatment to help protect your kidneys.
Show 3 more warnings
- This medicine can affect your bone marrow and cause changes in your blood cells. Your doctor will check your blood regularly.
- Use contraception during treatment and for at least 6 months after, and talk to your doctor about fertility concerns.
- Do not drive or operate machinery if the medicine causes symptoms that impair your ability.