Celecoxib Krka
Celecoxib Krka is a medicine that helps reduce pain and swelling caused by rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
How to Use
Dosage
The usual dose is 200 mg per day. Your doctor may increase it up to 400 mg per day. You can take one 200 mg capsule once daily or two 100 mg capsules twice daily.
Method
Swallow the capsule whole with water. You can take it with or without food, but try to take it at the same time each day.
The maximum daily dose is 400 mg.
Possible Side Effects
- •High blood pressure
- •Heart attack
- •Swelling (in ankles, legs, or hands)
- •Urinary tract infection
- •Breathing difficulties, sinus infection, stuffy nose, sore throat, cough, cold-like symptoms
- •Dizziness, trouble sleeping
- •Vomiting, stomach pain, diarrhea, indigestion, gas
- •Skin issues: rash, itching
- •Muscle stiffness
- •Difficulty swallowing
- •Headache
- •Nausea
- •Joint pain
- •Worsening of existing allergies
- •Accidents
- •Chest pain during exertion
- •Irritable bowel syndrome (stomach pain, diarrhea, indigestion, gas)
- •Kidney stones (stomach or back pain, blood in urine), difficulty urinating
- •Weight gain
- •Stroke
- •Heart failure, palpitations, fast heartbeat
- •Abnormal liver or kidney test results in blood
- •Anemia (fatigue, shortness of breath)
- •Anxiety, depression, tiredness, drowsiness, tingling skin
- •High potassium in blood (nausea, fatigue, muscle weakness, palpitations)
- •Blurred vision or decreased vision, ringing in ears, mouth sores, hearing problems
- •Constipation, burping, stomach inflammation, worsened digestive tract inflammation
- •Leg cramps
- •Hives (raised itchy rash)
- •Eye inflammation
- •Breathing difficulties
- •Bruises (skin discoloration)
- •Chest pain (general pain, not heart-related)
- •Facial swelling
- •Stomach or intestinal ulcers or ruptures (bleeding, abdominal pain, fever, vomiting, dark stool)
- •Pancreatitis, esophagitis
- •Low sodium in blood
- •Decreased white blood cells and platelets
- •Muscle coordination problems
- •Confusion, changes in taste
- •Increased sensitivity to light
- •Hair loss
- •Hallucinations
- •Bleeding in the eye
- •Lung inflammation
- •Irregular heartbeat
- •Skin redness and flushing
- •Blood clot in lungs (shortness of breath, chest pain, fainting)
- •Severe liver inflammation (hepatitis), liver damage, liver failure (nausea, diarrhea, jaundice, dark urine, pale stool, itching, chills)
- •Acute kidney failure, kidney inflammation, other kidney problems
- •Menstrual problems
- •Severe allergic skin reactions (e.g., Stevens-Johnson syndrome, blisters, peeling skin)
- •Brain hemorrhage
- •Meningitis
- •Worsening of epilepsy
- •Vision loss (blood vessel blockage in eye)
- •Vasculitis (blood vessel inflammation)
- •Loss of smell or taste
- •Reduced fertility in women (usually reversible after stopping treatment)
Important Warnings
- Do not take this medicine if you are allergic to celecoxib or sulfonamides (like some antibiotics).
- Do not take this medicine if you have stomach or intestinal ulcers or bleeding.
- Do not take this medicine if you have had asthma or a severe allergic reaction (e.g., rash, face swelling, breathing difficulty) after taking aspirin or other pain relievers.
- Do not use if you are pregnant, breastfeeding, or trying to get pregnant without effective contraception.
- Do not use if you have severe liver or kidney problems.
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- Do not use if you have inflammatory bowel disease (e.g., Crohn's disease).
- Do not use if you have severe heart failure or heart/brain blood vessel disease (e.g., heart attack, stroke).
- Talk to your doctor if you are taking aspirin (low dose) or other blood-thinning medicines.
- Talk to your doctor if you are taking other anti-inflammatory pain relievers (except aspirin).
- Talk to your doctor if you smoke, have diabetes, high blood pressure, or high cholesterol.
- Talk to your doctor if you have heart, liver, or kidney problems, or if you retain fluid in your body.
- Talk to your doctor if you have an infection, as this medicine can hide fever.
Use in Elderly Patients
Suitable for older adults, with specific precautions. For short-term use only. Consider adverse renal effect in chronic kidney disease. Do not use in severe renal impairment. May increase swelling. Worsens renal and cardiac failure and causes cardiovascular events. Risk of gastrointestinal bleeding less than with traditional NSAIDs. Consider potential interactions especially with preparations that increase risk of bleeding. (updated 16.9.2024)