Carmustine Accordpharma
Carmustine Accordpharma is a cancer medicine that slows down the growth of cancer cells.
Form
kuiva-aine ja liuotin välikonsentraatiksi infuusionestettä varten, liuos
Strength
50 mg
Active Ingredient
Carmustine
Manufacturer
Accord Healthcare B.V.
How to Use
Dosage
Your doctor will decide your dose based on your illness and body size. It is usually given every six weeks, 150-200 mg/m² as a single dose or split into 75-100 mg/m² per day for two days.
Method
The medicine is given as a drip (infusion) into a vein over 1–2 hours. The infusion must last at least one hour to prevent pain at the injection site.
Important
The maximum daily dose is 100 mg/m², if the dose is split over several days.
Possible Side Effects
COMMON
- •Delayed bone marrow suppression (fewer blood cells in the bone marrow), which can increase the risk of infections if white blood cells are low.
- •Problems with muscle coordination.
- •Feeling dizzy.
- •Headache.
- •Temporary eye redness, blurry vision due to bleeding in the retina.
- •Low blood pressure.
- •Inflammation of veins, with pain, swelling, redness, and tenderness.
- •Lung problems and trouble breathing.
- •Severe (possibly fatal) lung damage, which can happen years after treatment.
- •Severe nausea and vomiting.
- •Skin inflammation (dermatitis) when applied to the skin.
- •Accidental skin contact may cause temporary darkening of skin or nails.
- •Acute leukemias and abnormal bone marrow development. Symptoms include bleeding gums, bone pain, fever, repeated infections, nosebleeds, swollen lymph nodes, pale skin, shortness of breath, weakness, or tiredness.
- •Anemia (fewer red blood cells in the blood).
- •Brain disease. Symptoms include muscle weakness, trouble making decisions or focusing, involuntary movements, tremors, trouble speaking or swallowing, or seizures.
- •Not feeling hungry.
- •Constipation.
- •Diarrhea.
- •Inflammation of the mouth and lips.
- •Temporary liver problems with high doses, seen as changes in blood tests.
- •Hair loss.
- •Redness of the skin.
- •Reactions at the place where the injection was given.
RARE
- •A liver problem where small veins in the liver get blocked. Symptoms include fluid in the belly, enlarged spleen, severe bleeding from the food pipe, and yellow skin or eyes.
- •Breathing problems caused by lung scarring (interstitial fibrosis) at low doses.
- •Kidney problems.
- •Breast growth in men.
Important Warnings
- Do not use this medicine if you are allergic to carmustine or any of its ingredients.
- Do not use if your bone marrow is not producing enough blood cells (platelets, white blood cells, red blood cells) due to chemotherapy or other reasons.
- Do not use if you have severe kidney problems.
- This medicine must not be given to children and adolescents under 18 years of age.
- Do not breastfeed while using this medicine or for 7 days after.
Show 2 more warnings
- This medicine can cause severe lung damage, which may appear years after treatment. Contact a doctor immediately if you experience shortness of breath, persistent cough, chest pain, or constant tiredness.
- Do not use if you are pregnant, as it can harm the unborn baby. Use reliable contraception during treatment and for 6 months after (for both men and women).