Buprenorphine/Naloxone G.L. Pharma
Buprenorphine/Naloxone G.L. Pharma is used to treat opioid addiction in adults and adolescents over 15 years old, as part of a broader treatment plan.
Form
resoribletti
Strength
8 mg / 2 mg
Active Ingredient
Buprenorphine hydrochloride
Manufacturer
G.L. Pharma GmbH
How to Use
Dosage
The usual starting dose for adults and adolescents over 15 is 1-2 tablets (2 mg/0.5 mg) per day, with additional doses given on the first day if needed.
Method
Take the medicine once a day by placing the tablets under your tongue. Let them dissolve completely (about 5-10 minutes) without chewing or swallowing. Do not eat or drink until the tablets have fully dissolved.
Important
The maximum daily dose is 24 mg buprenorphine.
Possible Side Effects
COMMON
- •Insomnia
- •Constipation
- •Nausea
- •Excessive sweating
- •Headache
- •Drug withdrawal syndrome
- •Weight loss
- •Swelling (hands and feet)
- •Drowsiness
- •Anxiety
- •Nervousness
- •Tingling
- •Depression
- •Decreased sex drive
- •Increased muscle tension
- •Abnormal thoughts
- •Increased tear production (watery eyes) or other tear disorder
- •Blurred vision
- •Flushing
- •Increased blood pressure
- •Migraine
- •Runny nose
- •Sore throat and pain when swallowing
- •Increased cough
- •Abdominal discomfort or pain
- •Diarrhea
- •Abnormal liver function test results
- •Flatulence
- •Vomiting
- •Rash
- •Itching
- •Hives
- •Pain
- •Joint pain
- •Muscle pain
- •Leg cramps (muscle spasms)
- •Difficulty getting or keeping an erection
- •Abnormal urine
- •Stomach pain
- •Back pain
- •Weakness
- •Infection
- •Chills
- •Chest pain
- •Fever
- •Flu-like symptoms
- •General discomfort
- •Injury due to reduced alertness or coordination
- •Fainting
- •Dizziness
RARE
- •Swelling of glands (lymph nodes)
- •Restlessness
- •Tremor
- •Abnormal dreams
- •Excessive muscle activity
- •Depersonalization (feeling as if you are not yourself)
- •Drug dependence
- •Memory loss
- •Loss of interest
- •Excessive feeling of well-being
- •Convulsions
- •Speech disorder
- •Small pupils
- •Difficulty urinating
- •Eye inflammation
- •Fast or slow heart rate
- •Low blood pressure
- •Palpitations
- •Heart attack
- •Chest tightness
- •Shortness of breath
- •Asthma
- •Yawning
- •Pain and sores in the mouth
- •Tongue discoloration
- •Acne
- •Skin nodules
- •Hair loss
- •Dry or flaky skin
- •Joint inflammation
- •Urinary tract infection
- •Abnormal blood test results
- •Blood in urine
- •Abnormal ejaculation
- •Vaginal or menstrual problems
- •Kidney stones
- •Protein in urine
- •Pain when urinating or difficulty urinating
- •Sensitivity to heat or cold
- •Heat stroke
- •Loss of appetite
- •Feeling of hostility
Important Warnings
- If you are allergic to buprenorphine, naloxone, or any other ingredients in this medicine.
- If you have severe breathing problems.
- If you have severe liver problems.
- If you are intoxicated by alcohol or have tremors, sweating, anxiety, confusion, or hallucinations due to alcohol.
- If you are taking naltrexone or nalmefene for alcohol or opioid dependence treatment.
Show 11 more warnings
- Do not give this medicine to others. It can cause death or harm them.
- This medicine can cause severe, possibly fatal, breathing difficulties, especially in children or non-dependent individuals who take it accidentally or intentionally.
- If you experience breathing pauses during sleep, wake up at night due to shortness of breath, or are very sleepy during the day, contact your doctor.
- This medicine can cause dependence.
- The medicine can cause withdrawal symptoms if taken too soon after other opioids (less than 6 hours after short-acting opioids or less than 24 hours after long-acting opioids).
- Do not stop taking the medicine suddenly, as it can cause withdrawal symptoms.
- Tell your doctor about liver problems before starting treatment; your doctor may monitor your liver with blood tests.
- Swelling of the face, lips, tongue, or throat, difficulty swallowing or breathing, or severe rash (signs of a life-threatening allergic reaction). Seek immediate medical help.
- Severe tiredness, lack of coordination, blurred vision, slurred speech, impaired thinking, or unusually slow breathing. Seek immediate medical help.
- Very severe tiredness, itching, and yellowing of the skin or eyes (may be signs of liver damage).
- Seeing or hearing things that are not there (hallucinations).