Buprenorphine G.L. Pharma
This medicine is an opioid painkiller used to treat strong pain after surgery in adults.
Form
resoribletti
Strength
0.4 mg
Active Ingredient
Buprenorphine hydrochloride
Manufacturer
G.L. Pharma GmbH
How to Use
Dosage
Adults usually take 0.2-0.4 mg every 6-8 hours as needed. For older patients, 0.2 mg per dose is often enough.
Method
Place the tablet under your tongue and let it dissolve completely for 5-10 minutes; do not suck, chew, or swallow the tablet.
Important
Do not take more than 0.4 mg per dose, and do not exceed 1.6 mg in a 24-hour period (if taken every 6 hours).
Possible Side Effects
COMMON
- •Feeling very sleepy (sedation)
- •Dizziness
- •Spinning sensation (vertigo)
- •Nausea
- •Headache
- •Small pupils
- •Low blood pressure when standing up (orthostatic hypotension)
- •Reduced breathing (hypoventilation)
- •Vomiting
- •Increased sweating (hyperhidrosis)
RARE
- •Confusion
- •Euphoric mood
- •Nervousness
- •Depression
- •Psychotic disorder (perceptual disorder)
- •Hallucinations
- •Feeling detached from oneself (depersonalization)
- •Speech disorder (dysarthria)
- •Tingling or numbness (paresthesia)
- •Coma
- •Tremor
- •Blurred vision
- •Double vision (diplopia)
- •Vision disorder
- •Conjunctivitis (inflammation of the eye's outer membrane)
- •Ringing in the ears (tinnitus)
- •Fast heart rate (tachycardia)
- •Slow heart rate (bradycardia)
- •Bluish skin discoloration (cyanosis)
- •Second-degree atrioventricular block (heart conduction problem)
- •High blood pressure
- •Pale skin (pallor)
- •Shortness of breath (dyspnea)
- •Breathing cessation (apnea)
- •Reduced appetite
- •Constipation
- •Indigestion (dyspepsia)
- •Flatulence (gas)
- •Itching
- •Rash
- •Urinary retention (difficulty emptying bladder)
- •Weakness (asthenia)
- •Fatigue
- •General feeling of discomfort (malaise)
- •Hypersensitivity reactions
- •Decreased appetite
- •Low mood
- •Restlessness
- •Seizures
- •Coordination disorders
- •Diarrhea
- •Hives (urticaria)
- •Bronchospasm (spasms in bronchial muscles)
Important Warnings
- Do not take if you are allergic to buprenorphine, central nervous system pain medicines, or any other ingredient in this medicine.
- Do not take if you have severe breathing problems.
- Do not take if you have severe liver disease.
- Do not take if you are intoxicated by alcohol or have confusion due to alcohol withdrawal (delirium tremens).
- Tell your doctor if you have breathing difficulties like chronic lung disease, asthma, or low oxygen levels.
Show 13 more warnings
- Tell your doctor if you have had head or brain injuries, or increased pressure in your brain.
- Tell your doctor if you have a history of drug abuse or emotional instability.
- Tell your doctor if you are taking or have recently taken medicines that affect your brain or breathing (e.g., make you sleepy).
- Tell your doctor if you have liver problems or bile duct disease.
- Tell your doctor if you have kidney problems or adrenal gland insufficiency (Addison's disease).
- Tell your doctor if you have depression or other mental health conditions, as combining this medicine with certain antidepressants can lead to a serious condition called serotonin syndrome.
- Tell your doctor if you have sudden stomach pain.
- Tell your doctor if you have thyroid problems, such as myxedema or an underactive thyroid (hypothyroidism).
- Tell your doctor if you have a drug-induced mood disorder (toxic psychosis), central nervous system depression, or coma.
- Tell your doctor if you have an enlarged prostate or a blockage in your urinary tract.
- Tell your doctor if you have a curved spine that affects your breathing.
- Tell your doctor if you have recently been treated with opioid painkillers.
- Tell your doctor if you are dependent on opioids like methadone or heroin, as you may experience withdrawal symptoms.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Sedative. Low transdermal efficacy in cachectic patients. Increases the risk of confusion and falling. Need for laxative is often necessary. (updated 24.3.2025)