Bensylpenicillin Noridem
Bensylpenicillin Noridem is an antibiotic that kills specific bacteria causing infections in adults, adolescents, children, newborns, and premature babies.
How to Use
Dosage
For adults and adolescents 12 years and older, the usual daily dose is 0.6-3 g divided into 4-6 doses, which can be increased to 6-24 g/day for severe infections. For children, newborns, and premature babies, the dose is calculated based on body weight, typically 0.018-0.06 g/kg/day, divided into 2-6 doses, and can be increased for severe infections.
Method
This medicine is given by a doctor as an injection into a muscle or a vein. Intravenous administration can be a quick injection or a short infusion lasting 30-60 minutes.
The maximum daily dose for adults can be up to 24 g for severe infections. For children, it can be up to 0.6 g/kg/day for severe infections.
Possible Side Effects
- •Changes in laboratory test results.
- •Allergic reactions, including hives, rash, itching, and severe reactions such as difficulty breathing, swelling of the face, lips, or tongue (angioedema), and severe whole-body allergic reactions (anaphylaxis).
- •Severe skin reactions, such as widespread rash with blisters and peeling skin (Stevens-Johnson syndrome, toxic epidermal necrolysis), red scaly rash with bumps and blisters (exanthematous pustulosis), or widespread peeling skin inflammation (exfoliative dermatitis).
- •Flu-like symptoms with rash, fever, swollen lymph nodes, and abnormal blood test results (DRESS syndrome).
- •Jarisch-Herxheimer reaction (sudden fever, chills, skin redness, headache, muscle and joint pain, tiredness) which can occur when treating Lyme borreliosis or syphilis.
- •Diarrhea, which could indicate inflammation of the large intestine.
- •Nausea and vomiting.
- •Fever.
- •Joint pain.
- •Inflammation of the mucous membranes in the mouth or tongue (glossitis), sometimes described as black hairy tongue.
- •Neurological issues like seizures or loss of consciousness (metabolic encephalopathy), especially with high doses or rapid infusion.
- •Changes in blood cell counts (e.g., increased eosinophils, decreased white blood cells, hemolytic anemia) and blood clotting disorders.
- •Kidney disease, abnormal findings in urine (e.g., protein, blood, casts), and decreased urine production or inability to urinate.
- •Liver inflammation (hepatitis) and reduced bile flow in the gallbladder (cholestasis).
- •Severe local reactions at the injection site, especially when given as a muscle injection to infants.
- •Serum sickness, an allergic reaction to blood proteins with symptoms like fever, swollen lymph nodes, redness at injection site, and itching.
- •Prolonged bleeding time and clotting time in blood tests.
Important Warnings
- Do not use if you are allergic to benzylpenicillin or have had a severe allergic reaction to penicillin before, as this could be life-threatening.
- Inform your doctor if you have had a severe allergic reaction to other beta-lactam antibiotics (e.g., cephalosporins, carbapenems).
- If you have kidney or liver problems, your doctor may need to adjust your dose.
- If you have epilepsy, fluid in the brain, or meningitis, your doctor will monitor you closely due to an increased risk of seizures.
- Long-term treatment can lead to overgrowth of other bacteria or fungi. Tell your doctor if you experience diarrhea, itchy rash, or fungal infections.
Show 2 more warnings
- If you develop severe, persistent diarrhea during treatment, tell your doctor immediately, as it could be a serious bowel inflammation.
- Rapid infusion can cause seizures, especially with high doses.