Bendamustine Fresenius Kabi
Bendamustine Fresenius Kabi is a medicine used to treat certain types of cancer, either alone or with other medications.
Form
kuiva-aine välikonsentraatiksi infuusionestettä varten, liuos
Strength
2.5 mg/ml
Active Ingredient
Bendamustine hydrochloride
Manufacturer
Fresenius Kabi AB
How to Use
Dosage
Your doctor will determine the dose based on your condition and body size.
Method
The medicine is given as an infusion into a vein for 30-60 minutes.
Important
Your doctor will determine the maximum daily dose based on your specific treatment plan.
Possible Side Effects
COMMON
- •Low white blood cell count
- •Reduced hemoglobin levels
- •Low platelet count
- •Infections
- •Nausea
- •Vomiting
- •Sores in the mouth or throat (mucositis)
- •Increased blood creatinine levels
- •Increased blood urea levels
- •Fever
- •Fatigue
- •Headache
- •Bleeding
- •Changes in body chemicals due to cancer cells breaking down (tumor lysis syndrome)
- •Low red blood cell count, making you feel tired or pale (anemia)
- •Low neutrophil count (a type of white blood cell)
- •Allergic reactions, like skin rash or hives
- •Changes in liver function tests (increased ASAT/ALAT enzyme levels)
- •Increased alkaline phosphatase enzyme levels
- •Increased bile pigment levels (bilirubin)
- •Low potassium in your blood
- •Heart problems, like a fast heartbeat or chest pain
- •Irregular heart rhythm (arrhythmias)
- •Low or high blood pressure
- •Breathing problems (lung function disorders)
- •Diarrhea
- •Constipation
- •Mouth pain (stomatitis)
- •Loss of appetite
- •Hair loss
- •Skin changes
- •Absence of menstruation
- •Pain
- •Insomnia
- •Chills
- •Dehydration
- •Dizziness
- •Itchy rash (hives)
RARE
- •Fluid accumulation around the heart (pericardial effusion)
- •Insufficient blood cell production in bone marrow
- •Acute leukemia
- •Heart attack, chest pain
- •Heart failure
- •Blood poisoning (sepsis)
- •Severe allergic hypersensitivity reactions (anaphylactic reactions)
- •Bone marrow depression
- •Anaphylactoid reactions (symptoms similar to allergic reactions)
- •Drowsiness
- •Hoarseness
- •Acute circulatory failure (shock)
- •Skin redness
- •Skin inflammation (dermatitis)
- •Itching
- •Flat or raised red spots on the skin (maculopapular rash)
- •Excessive sweating
- •Primary atypical pneumonia
- •Red blood cell breakdown (hemolysis)
- •Rapid drop in blood pressure, possibly with skin reactions or rash (anaphylactic shock)
- •Taste disturbance
- •Sensory disturbances (paresthesia)
- •Nerve damage in arms or legs, causing pain or discomfort (peripheral neuropathy)
- •Severe condition due to blockage of specific nervous system receptors
- •Nervous system disorders
- •Coordination disorders
- •Brain inflammation (encephalitis)
- •Rapid heartbeat (tachycardia)
- •Vein inflammation (phlebitis)
- •Scarring in the lungs (pulmonary fibrosis)
- •Inflammation of the food pipe with bleeding (hemorrhagic esophagitis)
- •Stomach or intestinal bleeding
- •Infertility
- •Damage to multiple organs (multi-organ damage)
- •Liver failure
- •Kidney failure
- •Irregular and often rapid heartbeat (atrial fibrillation)
- •Severe skin reactions, including widespread painful rash with blisters and peeling skin (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis, or DRESS)
- •Drug rash when used with rituximab
- •Lung inflammation (pneumonitis)
- •Lung bleeding
- •Increased thirst and urination (nephrogenic diabetes insipidus)
Important Warnings
- Do not use if you are allergic to bendamustine hydrochloride or any other ingredient in this medicine.
- Do not use if you are breastfeeding; if treatment is necessary, breastfeeding must be stopped.
- Do not use if you have severe liver problems.
- Do not use if your skin or eyes are yellow due to liver or blood problems (jaundice).
- Do not use if you have severely reduced bone marrow function and severely abnormal white blood cell or platelet counts.
Show 8 more warnings
- Do not use if you have had major surgery within 30 days before starting treatment.
- Do not use if you have an infection, especially with a low white blood cell count.
- Do not use with yellow fever vaccination.
- Seek immediate medical attention if you experience memory loss, difficulty thinking, walking problems, or vision loss, as these could be signs of a rare but serious brain infection.
- Contact your doctor if you notice any suspicious skin changes, as there is an increased risk of certain types of non-melanoma skin cancers with this medicine.
- Seek medical attention if you develop a painful, red or purple rash that spreads and forms blisters, especially if you have had photosensitivity, respiratory infection, and/or fever.
- Watch for severe allergic or hypersensitivity reactions.
- Do not drive or operate machinery if you experience side effects such as dizziness or coordination problems.