Bendamustine Accord
Bendamustine Accord is a chemotherapy medicine used to treat certain types of cancer, including chronic lymphocytic leukemia, non-Hodgkin's lymphomas, and multiple myeloma.
Form
infuusiokonsentraatti, liuosta varten
Strength
25 mg/ml
Active Ingredient
Bendamustine hydrochloride monohydrate
Manufacturer
Accord Healthcare B.V.
How to Use
Dosage
The dosage varies and is calculated by your doctor based on your body surface area.
Method
This medicine is given as an infusion into a vein over 30-60 minutes.
Important
The maximum daily dose is 120-150 mg per square meter of body surface area, as determined by your doctor.
Possible Side Effects
COMMON
- •Low white blood cell count (cells that fight disease)
- •Decreased hemoglobin levels (protein in red blood cells that carries oxygen)
- •Low platelet count (cells that help blood clot)
- •Infections
- •Nausea
- •Vomiting
- •Mucositis (inflammation of mucous membranes)
- •Increased creatinine levels in blood (a waste product from muscles)
- •Increased urea levels in blood (a chemical waste product)
- •Fever
- •Fatigue
- •Headache
- •Bleeding
- •Metabolic disorders due to waste products from cancer cell breakdown
- •Reduced red blood cell count, causing paleness, weakness, or shortness of breath (anemia)
- •Low neutrophil count (a type of white blood cell that fights infections)
- •Hypersensitivity reactions, e.g., allergic rash and hives
- •Increased liver enzyme levels (ASAT/ALAT), which can indicate liver cell inflammation or damage
- •Increased alkaline phosphatase (AFOS) levels (an enzyme mainly produced in the liver and bones)
- •Increased bilirubin levels (a substance formed from the normal breakdown of red blood cells)
- •Decreased blood potassium levels (a nutrient needed for nerve and muscle cell function, including in the heart)
- •Heart rhythm disorders
- •Heart arrhythmias
- •Low or high blood pressure
- •Lung function disorders
- •Diarrhea
- •Constipation
- •Mouth pain (stomatitis)
- •Loss of appetite
- •Hair loss
- •Skin changes
- •Missed periods (amenorrhea)
- •Pain
- •Insomnia
- •Chills
- •Dehydration
- •Dizziness
- •Itchy hives (urticaria)
RARE
- •Fluid buildup around the heart (pericardial effusion)
- •Insufficient production of all blood cell types in the bone marrow
- •Acute leukemia
- •Heart attack, chest pain (myocardial infarction)
- •Heart failure
- •Blood poisoning (sepsis)
- •Severe allergic hypersensitivity reactions (anaphylactic reactions)
- •Symptoms resembling anaphylactic reactions
- •Drowsiness
- •Hoarseness
- •Acute circulatory failure (mainly heart-related)
- •Skin redness (erythema)
- •Rash (dermatitis)
- •Itching (pruritus)
- •Macular rash (macular exanthem)
- •Excessive sweating (hyperhidrosis)
- •Bone marrow failure, which can cause malaise and show in blood tests
- •Primary, atypical pneumonia
- •Breakdown of red blood cells (hemolysis)
- •Rapid drop in blood pressure, sometimes with skin reactions or rash (anaphylactic shock)
- •Taste disorders
- •Sensory disturbances
- •Peripheral nerve damage (discomfort and pain in limbs)
- •Serious condition leading to nerve receptor dysfunction (anticholinergic syndrome)
- •Nervous system disorders
- •Coordination disorders (ataxia)
- •Brain inflammation (encephalitis)
- •Rapid heartbeat (tachycardia)
- •Vein inflammation (phlebitis)
- •Fibrosis in the lungs (pulmonary fibrosis)
- •Esophageal inflammation with bleeding (hemorrhagic esophagitis)
- •Stomach or intestinal bleeding
- •Infertility
- •Multiple organ failure
- •Kidney failure
- •Liver failure
- •Irregular and often rapid heartbeat (atrial fibrillation)
- •Severe rash with blisters or peeling skin (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis)
- •Drug rash with combination therapy including rituximab
- •Lung inflammation (pneumonitis)
- •Lung bleeding
- •Excessive urination, including at night, and excessive thirst even after drinking fluids (nephrogenic diabetes insipidus)
Important Warnings
- Do not use this medicine if you are allergic to bendamustine or any other ingredients.
- You must not breastfeed during treatment.
- Do not use if you have severe liver problems or very low white blood cell or platelet counts due to poor bone marrow function.
- Do not use if you had a major surgery in the last 30 days.
- Tell your doctor if you have an infection, especially with a low white blood cell count.
Show 5 more warnings
- Inform your doctor if you have a history of heart problems like heart attacks or chest pain.
- Get immediate medical help if you get a severe rash with blisters, peeling skin, or sores in your mouth, eyes, or genitals, possibly with fever.
- Contact your doctor right away if you notice memory loss, trouble thinking, difficulty walking, or vision changes, as these can be signs of a serious brain infection.
- Talk to your doctor if you notice any suspicious skin changes, as this medicine may increase your risk of certain skin cancers.
- Do not use with yellow fever vaccine.