Azacitidine Tillomed
This medicine is a cancer drug that helps stop cancer cells from growing and is used to treat certain blood and bone marrow disorders.
Form
injektiokuiva-aine, suspensiota varten
Strength
25 mg/ml
Active Ingredient
Azacitidine
Manufacturer
Tillomed Pharma GmbH
How to Use
Dosage
The recommended dose is 75 mg per square meter of body surface area, adjusted by your doctor based on your health.
Method
It is given as an injection under the skin (thigh, abdomen, or upper arm) daily for one week, followed by a three-week break. This is repeated every four weeks for at least 6 cycles.
Important
The maximum daily dose is as prescribed by your doctor; doses over 4 ml will be split into two injection sites.
Possible Side Effects
COMMON
- •Low red blood cell count (anemia), causing tiredness and paleness.
- •Low white blood cell count, potentially leading to fever and increased risk of infections.
- •Low platelet count, increasing the risk of bleeding and bruising.
- •Constipation, diarrhea, nausea, vomiting.
- •Lung inflammation (pneumonia).
- •Chest pain, shortness of breath.
- •Tiredness.
- •Injection site reactions, including redness, pain, or skin reaction.
- •Loss of appetite.
- •Joint pain.
- •Bruising.
- •Rash.
- •Red or purple spots under the skin.
- •Abdominal pain.
- •Itching.
- •Fever.
- •Nose and throat pain.
- •Dizziness.
- •Headache.
- •Insomnia (difficulty sleeping).
- •Nosebleed.
- •Muscle pain.
- •Weakness.
- •Weight loss.
- •Low potassium levels in the blood.
RARE
- •Drowsiness, tremors, yellow skin (jaundice), abdominal swelling, and easy bruising, possibly signs of life-threatening liver failure.
- •Swelling of legs and feet, back pain, decreased urination, increased thirst, rapid pulse, dizziness, nausea, vomiting, decreased appetite, confusion, restlessness, or tiredness, possibly signs of life-threatening kidney failure.
- •Fever due to very low white blood cells, which can lead to life-threatening infections.
- •Chest pain or shortness of breath with fever, possibly severe lung inflammation (pneumonia).
- •Serious bleeding, such as blood in stool from stomach or intestinal bleeding, or bleeding inside the brain, caused by very low platelets.
- •Difficulty breathing, swollen lips, itching, or a rash, possibly signs of a severe allergic reaction.
- •Bleeding inside the head.
- •Bacterial blood infection (sepsis), possibly due to low white blood cell count.
- •Bone marrow failure, leading to low red, white, and platelet cell counts.
- •A type of anemia with reduced red and white blood cells and platelets.
- •Urinary tract infection.
- •Viral infection causing cold sores (herpes).
- •Gum bleeding, stomach or intestinal bleeding, bleeding from hemorrhoids, eye bleeding, bleeding under the skin.
- •Blood in urine.
- •Sores in the mouth or on the tongue.
- •Skin changes at injection site, including swelling, hardened lump, bruising, bleeding under skin, rash, itching, and skin discoloration.
- •Skin redness.
- •Skin infection (cellulitis).
- •Nose and throat infection or sore throat.
- •Nasal pain or runny nose or sinus pain (sinusitis).
- •High or low blood pressure.
- •Shortness of breath when moving.
- •Throat and larynx pain.
- •Indigestion.
- •Lethargy.
- •General feeling of unwellness.
- •Anxiety.
- •Confusion.
- •Hair loss.
- •Kidney failure.
- •Dehydration.
- •White coating on tongue, inside cheeks, sometimes palate, gums, and tonsils (oral fungal infection).
- •Fainting.
- •Drop in blood pressure when standing up (orthostatic hypotension), causing dizziness when rising.
- •Drowsiness, sleepiness.
- •Bleeding from a catheter tube.
- •Bowel disease with fever, vomiting, and stomach pain (diverticulitis).
- •Fluid buildup around the lungs (pleural effusion).
- •Chills.
- •Muscle spasms.
- •Itchy rash (hives).
- •Fluid buildup around the heart (pericardial effusion).
- •Allergic (hypersensitivity) reaction.
- •Tremors.
- •Liver failure.
- •Large, purple, painful raised skin patches with fever.
- •Painful skin ulcers (pyoderma gangrenosum).
- •Inflammation of the sac around the heart (pericarditis).
- •Dry cough.
- •Painless swelling of fingertips (clubbing).
- •Tumor lysis syndrome, a metabolic complication from dying cancer cells that can lead to kidney or heart problems, seizures, or death.
- •Serious deep skin infection that spreads quickly and can be life-threatening (necrotizing fasciitis).
- •Severe immune reaction (differentiation syndrome) with fever, cough, breathing difficulties, itching, decreased urine, low blood pressure, swollen limbs, and rapid weight gain.
- •Inflammation of blood vessels in the skin, causing rash (cutaneous vasculitis).
Important Warnings
- Do not use if you are allergic to azacitidine or any other ingredient in this medicine.
- Do not use if you have advanced liver cancer.
- Do not breastfeed while using this medicine.
- Talk to your doctor if you have low blood platelet, red, or white blood cell counts.
- Talk to your doctor if you have kidney, liver, heart, or lung disease.
Show 3 more warnings
- Do not use if you are pregnant, as it may harm the baby. Women who can become pregnant must use effective birth control during treatment and for 6 months after.
- Men should not father a child during treatment and for 3 months after, and must use effective contraception. Discuss sperm banking with your doctor before treatment.
- Do not drive or operate machinery if you experience side effects like tiredness.