Azacitidine SUN
Azacitidine SUN is a cancer medicine that stops cancer cells from growing and helps your bone marrow produce healthy blood cells.
Form
injektiokuiva-aine, suspensiota varten
Strength
25 mg/ml
Active Ingredient
Azacitidine
Manufacturer
Sun Pharmaceutical Industries Europe B.V.
How to Use
Dosage
Your doctor will determine your dose based on your general health, height, and weight; the recommended dose is usually 75 mg per square meter of body surface area.
Method
A doctor or nurse will give you this medicine as an injection under the skin in your thigh, abdomen, or upper arm.
Important
The medicine is given every day for one week, followed by a 3-week break; this treatment cycle is repeated every 4 weeks for at least 6 cycles.
Possible Side Effects
COMMON
- •Low red blood cells (anemia) causing tiredness and paleness.
- •Low white blood cells, leading to fever and infections.
- •Low platelets (thrombocytopenia), increasing risk of bleeding and bruising.
- •Nausea, vomiting.
- •Diarrhea.
- •Constipation.
- •Abdominal pain.
- •Loss of appetite.
- •Weight loss.
- •Fatigue, weakness, feeling unwell.
- •Headache.
- •Dizziness, lightheadedness (including when standing up).
- •Difficulty sleeping (insomnia).
- •Fever.
- •Chills.
- •Injection site reactions (pain, redness, swelling, hardening, bruising, rash).
- •Skin rash, itching.
- •Red or purple spots under the skin.
- •Muscle or joint pain.
- •Nosebleeds.
- •Sore throat, nose pain, sinus pain.
- •Chest pain, shortness of breath.
- •Pneumonia (lung inflammation).
- •High or low blood pressure.
- •Confusion, anxiety.
- •Hair loss.
- •Kidney problems.
- •Dehydration.
- •Oral thrush (white coating in mouth/on tongue).
- •Low potassium in blood.
- •Urinary tract infection.
- •Herpes virus infection (cold sores).
- •Skin infection (cellulitis).
- •Bleeding (e.g., in gums, stomach, intestines, eyes, under skin, from catheter, in head).
- •Bone marrow failure.
- •Swelling or fluid buildup (e.g., around lungs or heart).
- •Intestinal disease with fever, vomiting, stomach pain (diverticulitis).
- •Muscle spasms.
- •Hives (itchy welts).
- •Mouth or tongue sores.
RARE
- •Allergic (hypersensitivity) reaction.
- •Liver failure.
- •Large, raised, painful purple skin patches with fever.
- •Painful skin sores (pyoderma gangrenosum).
- •Inflammation of the sac around the heart (pericarditis).
- •Dry cough.
- •Painless swelling in fingertips (clubbing).
- •Tumor lysis syndrome (metabolic complications from dying cancer cells).
- •Rapidly spreading, life-threatening skin and tissue infection (necrotizing fasciitis).
- •Serious immune reaction (differentiation syndrome) with symptoms like fever, cough, difficulty breathing, rash, low urine, low blood pressure, swollen arms/legs, rapid weight gain.
- •Inflammation of blood vessels in the skin causing a rash (cutaneous vasculitis).
- •Tremors.
Important Warnings
- Do not use if you are allergic to azacitidine or any other ingredients in this medicine.
- Do not use if you have advanced liver cancer.
- Do not breastfeed if you are using this medicine.
- Talk to your doctor if you have low platelet, red blood cell, or white blood cell counts.
- Talk to your doctor if you have kidney or liver disease.
Show 5 more warnings
- Talk to your doctor if you have ever had heart or lung disease.
- Azacitidine SUN can cause a serious immune reaction called differentiation syndrome.
- Do not use this medicine during pregnancy as it can harm the baby. Use effective contraception during treatment and for 6 months afterwards.
- Men should not father children during this treatment. Use effective contraception during treatment and for 3 months afterwards.
- Do not drive or operate machinery if you feel tired or experience other side effects.