Amlodipin/Valsartan/Hydrochlorothiazide Orion
This medication lowers high blood pressure by combining three different active substances.
Form
tabletti, kalvopäällysteinen
Strength
10 mg / 320 mg / 25 mg
Active Ingredient
Amlodipine besylate
Manufacturer
Orion Corporation
How to Use
Dosage
One tablet daily.
Method
Take the tablet with a glass of water, preferably at the same time each morning, with or without food. Avoid grapefruit and grapefruit juice.
Important
Do not exceed the prescribed dose (one tablet per day).
Possible Side Effects
COMMON
- •Low blood potassium levels
- •Increased blood fat levels
- •Dizziness
- •Low blood pressure (feeling faint or dizzy)
- •Drowsiness
- •Palpitations (feeling your heart beat fast)
- •Flushing (redness of the skin)
- •Ankle swelling
- •Abdominal pain
- •Nausea after eating
- •Tiredness
- •Headache
- •Frequent urination
- •High uric acid in blood
- •Low blood magnesium levels
- •Low blood sodium levels
- •Dizziness or fainting when standing up
- •Decreased appetite
- •Nausea and vomiting
- •Itchy rash or other types of rashes
- •Inability to get or keep an erection
RARE
- •Severely reduced urine output (kidney problems)
- •Spontaneous bleeding
- •Irregular heartbeat
- •Liver problems
- •Sudden wheezing, chest pain, shortness of breath or difficulty breathing
- •Swelling of eyelids, face, or lips
- •Swelling of tongue and throat causing severe breathing difficulties
- •Severe skin reactions including severe rash, hives, redness, itching, blistering, peeling, or swelling of the skin (e.g., Stevens-Johnson syndrome)
- •Heart attack
- •Inflammation of the pancreas, causing severe abdominal and back pain with general unwellness
- •Weakness, bruising, fever, and frequent infections
- •Stiffness
- •Acute respiratory distress (severe shortness of breath, fever, weakness, confusion)
- •Fast heart rate
- •Spinning sensation
- •Visual disturbance
- •Unpleasant feeling in stomach
- •Chest pain
- •Increased creatinine and uric acid in blood
- •High calcium, fat, or sodium in blood
- •Decreased potassium in blood
- •Bad breath
- •Diarrhea
- •Dry mouth
- •Weight gain
- •Loss of appetite
- •Taste disturbance
- •Back pain
- •Joint swelling
- •Muscle cramps, weakness, or pain
- •Limb pain
- •Inability to stand or walk normally
- •Weakness
- •Abnormal coordination
- •Dizziness when standing up or after exercise
- •Lack of energy
- •Sleep disturbances
- •Tingling or numbness
- •Neuropathy (nerve damage)
- •Sudden, temporary loss of consciousness
- •Low blood pressure upon standing
- •Cough
- •Shortness of breath
- •Throat irritation
- •Excessive sweating
- •Itching
- •Swelling, redness, and pain along a vein
- •Skin redness
- •Tremors
- •Mood changes
- •Anxiety
- •Depression
- •Insomnia
- •Taste disorders
- •Fainting
- •Loss of pain sensation
- •Visual disturbances
- •Impaired vision
- •Ringing in the ears
- •Sneezing/runny nose due to nasal inflammation
- •Changes in bowel habits
- •Indigestion
- •Hair loss
- •Skin discoloration
- •Urination disorders
- •Increased need to urinate at night
- •Breast enlargement or discomfort in men
- •Pain
- •Malaise (general unwellness)
- •Weight loss
- •Low platelet count (may cause bleeding or bruising)
- •Sugar in urine
- •High blood sugar levels
- •Worsening of diabetic metabolic state
- •Constipation
- •Liver problems (e.g., yellow skin/eyes, dark urine)
- •Increased skin sensitivity to sun
- •Reddish-purple spots on the skin
- •Kidney problems
- •Confusion
- •Decreased white blood cell count
- •Low platelet count leading to easy bruising or bleeding
- •Gum swelling
- •Abdominal swelling (gastritis)
- •Liver inflammation (hepatitis)
- •Jaundice (yellow skin)
- •Elevated liver enzymes (may affect lab results)
- •Increased muscle tension
- •Blood vessel inflammation (often with skin rash)
- •Photosensitivity (increased sensitivity to light)
- •Conditions with stiffness, tremors, and/or movement disorders
- •Fever, sore throat or mouth ulcers, frequent infections (low white blood cells)
- •Pale skin, fatigue, shortness of breath, dark urine (hemolytic anemia)
- •Confusion, fatigue, muscle twitching, muscle cramps, fast breathing (hypochloremic alkalosis)
- •Severe upper abdominal pain (pancreatitis)
- •Intestinal swelling with symptoms like abdominal pain, nausea, vomiting, and diarrhea
- •Breathing difficulties with fever, cough, wheezing, shortness of breath (e.g., lung edema, pneumonia)
- •Facial rash, joint pain, muscle disorders, fever (lupus erythematosus)
- •Inflammation of blood vessels with rash, purplish-red spots, fever (vasculitis)
- •Severe skin disease with rash, red skin, blisters on lips, eyes or mouth, peeling skin, fever (toxic epidermal necrolysis)
- •Changes in kidney function blood tests, increased potassium in blood, low red blood cell count
- •Abnormal red blood cell test
- •Low levels of certain white blood cells and platelets
- •Increased creatinine in blood
- •Abnormal liver function tests
- •Inflammation of blood vessels
- •Weakness, bruising, and frequent infections (aplastic anemia)
- •Decreased vision or eye pain due to high pressure (fluid buildup in the eye, acute angle-closure glaucoma)
- •Blistering rash on the skin
Important Warnings
- Do not take if you are more than 3 months pregnant. Not recommended in early pregnancy.
- Do not take if you are allergic to any of the ingredients.
- Do not take if you have severe liver or kidney problems, or if you cannot produce urine.
- Do not take if your blood potassium or sodium levels are too low, or calcium levels are too high.
- If you experience decreased vision or eye pain, seek immediate medical attention.
Show 3 more warnings
- This medicine can increase your risk of skin or lip cancer. Protect your skin from sun and tell your doctor about any new skin changes.
- If you develop severe shortness of breath after taking this medicine, seek immediate medical help.
- Do not eat grapefruit or drink grapefruit juice while taking this medicine.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Effectiveness is reduced in renal impairment. Consider risk of orthostatic hypotension and hyponatraemia and -kalemia. (updated 19.5.2025)