Amlodipin/Valsartan/Hydrochlorothiazide Orion
This medicine contains three ingredients that work together to lower high blood pressure.
Form
tabletti, kalvopäällysteinen
Strength
5 mg / 160 mg / 12.5 mg
Active Ingredient
Amlodipine besylate
Manufacturer
Orion Corporation
How to Use
Dosage
The usual dose is one tablet per day.
Method
Take the tablet at the same time each day, preferably in the morning, with a glass of water, with or without food. Do not take with grapefruit or grapefruit juice.
Important
Do not exceed the dose prescribed by your doctor.
Possible Side Effects
COMMON
- •Dizziness
- •Low blood pressure (feeling weak, dizzy, fainting)
- •Low blood potassium levels
- •Increased blood lipid (fat) levels
- •Drowsiness
- •Palpitations (feeling your heartbeat)
- •Flushing (skin redness)
- •Ankle swelling
- •Stomach pain
- •Nausea after eating
- •Fatigue
- •Headache
- •Frequent urge to urinate
- •High blood uric acid levels
- •Low blood magnesium levels
- •Low blood sodium levels
- •Decreased appetite
- •Nausea and vomiting
- •Itchy rash
- •Inability to get or keep an erection
RARE
- •Severely reduced urine output (kidney problems)
- •Spontaneous bleeding or easy bruising
- •Irregular heartbeat
- •Liver problems (e.g., yellow skin or eyes)
- •Sudden severe breathing issues (wheezing, shortness of breath)
- •Swelling of face, lips, tongue, or throat
- •Severe skin reactions (blistering, peeling skin, widespread rash)
- •Heart attack
- •Inflammation of the pancreas (severe stomach and back pain)
- •Unexplained weakness, fever, or frequent infections
- •Muscle stiffness or difficulty moving
- •Sudden temporary loss of consciousness
- •Spinning sensation (vertigo)
- •Vision problems or eye pain
- •Chest pain (non-cardiac)
- •Diarrhea or dry mouth
- •Weight gain or loss
- •Taste changes
- •Back pain or joint swelling
- •Muscle cramps or limb pain
- •Tingling or numbness
- •Cough or sore throat
- •Excessive sweating
- •Mood changes (anxiety, depression)
- •Hair loss
- •Skin discoloration
- •Blistering skin rash
- •Increased skin sensitivity to sunlight
- •Skin or lip cancer (non-melanoma type)
Important Warnings
- Do not take this medicine if you are more than 3 months pregnant or trying to get pregnant, as it can harm your baby.
- Do not take this medicine if you are allergic to amlodipine, valsartan, hydrochlorothiazide, sulfonamide medicines, or any other ingredient in this medicine.
- Do not take this medicine if you have severe liver problems or a condition where bile cannot flow from your liver.
- Do not take this medicine if you have severe kidney problems, are on dialysis, or if your body does not produce urine.
- Do not take this medicine if your blood potassium or sodium levels are too low, even with treatment.
Show 7 more warnings
- Do not take this medicine if you have very low blood pressure.
- If you experience swelling of your face or throat, stop taking this medicine immediately and contact your doctor. Do not take this medicine again.
- If you notice vision loss or eye pain, contact your doctor immediately, as these could be signs of a serious eye problem that can lead to permanent vision loss if untreated.
- This medicine can increase your risk of skin or lip cancer, especially with long-term, high-dose use. Protect your skin from sun and UV light.
- If you have previously had breathing problems after taking hydrochlorothiazide, or if you develop severe shortness of breath after taking this medicine, seek immediate medical attention.
- Do not consume grapefruit or grapefruit juice while taking this medicine.
- This medicine may cause dizziness, drowsiness, nausea, or headaches. If you experience these symptoms, do not drive or use machines.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Effectiveness is reduced in renal impairment. Consider risk of orthostatic hypotension and hyponatraemia and -kalemia. (updated 19.5.2025)