Amitriptylin Abcur
Amitriptylin Abcur is a medicine used to treat depression, nerve pain, and to prevent tension headaches and migraines, as well as for bedwetting in children.
Form
tabletti, kalvopäällysteinen
Strength
50 mg
Active Ingredient
Amitriptyline hydrochloride
Manufacturer
Abcur AB
How to Use
Dosage
For adults, the usual starting dose is 25 mg twice a day for depression, or 10-25 mg in the evening for nerve pain, headache prevention, or migraine prevention. Doses can be adjusted by your doctor.
Method
Take this medicine with or without food. Swallow the tablets whole with water; do not chew them.
Important
For adults, the maximum daily dose is usually 150 mg, but your doctor will decide the right dose for you. Do not stop taking this medicine or change your dose without talking to your doctor.
Possible Side Effects
COMMON
- •Drowsiness or sleepiness
- •Shaking in your hands or other body parts
- •Dizziness
- •Headache
- •Uneven, strong, or fast heartbeat
- •Dizziness when standing up due to low blood pressure
- •Dry mouth
- •Constipation
- •Nausea
- •Excessive sweating
- •Weight gain
- •Slurred or slow speech
- •Aggression
- •Stuffy nose
- •Confusion
- •Changes in sexual desire or ability (e.g., problems getting an erection)
- •Difficulty concentrating
- •Changes in taste
- •Numbness or tingling in hands or feet
- •Problems with coordination
- •Enlarged pupils
- •Heart block (a type of irregular heartbeat)
- •Tiredness
- •Low sodium levels in blood
- •Agitation, physical restlessness
- •Urination problems
- •Thirst
- •Heart problem called 'prolonged QT interval' (seen on an ECG)
RARE
- •Temporary blurred vision, seeing colored rings around lights, and eye pain (these could be signs of acute glaucoma, a serious eye condition)
- •Severe constipation, swollen stomach, fever, and vomiting (these might mean your bowels are not moving properly)
- •Yellow skin or eyes (jaundice), liver problems
- •Easy bruising, bleeding, pale skin, long-lasting sore throat, or fever (these can be signs of blood or bone marrow problems)
- •Suicidal thoughts or behavior
- •Agitation, anxiety, sleep problems, nightmares
- •Seizures or convulsions
- •Ringing in the ears (tinnitus)
- •High blood pressure
- •Diarrhea, vomiting
- •Rash, hives, swelling of face or tongue
- •Increased breast milk production or discharge
- •Worsening heart failure
- •Reduced appetite
- •Delirium (confusion, loss of reality), hallucinations
- •Swelling of salivary glands
- •Hair loss
- •Increased sensitivity to sunlight
- •Breast growth in men
- •Weight loss
- •Abnormal liver test results
- •Heart muscle disease
- •Feeling restless and a strong need to move constantly
- •Nerve problems (e.g., numbness, tingling, reduced touch sensation in legs and feet)
- •Sudden increase in eye pressure
- •Specific abnormal heart rhythms (e.g., Torsades de pointes)
- •Allergic inflammation of lung tissue
- •No feeling of hunger
- •High or low blood sugar levels
- •Paranoia or delusions
- •Movement disorders (involuntary or reduced movements)
- •Heart muscle inflammation due to hypersensitivity
- •Liver inflammation
- •Hot flashes
- •Dry eyes
Important Warnings
- Always talk to your doctor or pharmacist before taking this medicine.
- High doses can cause heart rhythm problems or low blood pressure. This can also happen with normal doses if you already have heart disease.
- This medicine can affect your heart's rhythm (seen on an ECG). Tell your doctor if you have a slow heart rate, heart failure, are taking other heart medicines, have low or high potassium, or have an overactive thyroid.
- If you feel depressed, you might sometimes think about harming yourself or ending your life. These thoughts can increase when you first start taking antidepressants. If you ever have thoughts of harming yourself, contact your doctor or go to a hospital right away.
- Some people with bipolar disorder might experience a manic phase, with a lot of fast thoughts, extreme happiness, and high energy. If this happens, contact your doctor as your medication might need to be changed.
Show 6 more warnings
- Tell your doctor if you have or have had any medical conditions like glaucoma, epilepsy or seizures, problems urinating, an enlarged prostate, thyroid disease, bipolar disorder, schizophrenia, severe liver or heart disease, or diabetes.
- This medicine should not be given to children under 6 years old.
- Do not drink alcohol while taking this medicine, as it can make you more drowsy.
- If you are pregnant, breastfeeding, or planning to have a baby, talk to your doctor before using this medicine. It is generally not recommended during pregnancy unless your doctor considers it essential.
- This medicine can make you feel sleepy or dizzy, especially at the start of treatment. Do not drive or operate machinery if you feel these effects.
- This medicine contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Use in Elderly Patients
Category D
Avoid use in older adults. Anticholinergic. Sedative. Serotonergic. Risk of QT prolongation. Significant adverse effects include confusion, cognitive impairment, arrhythmias and orthostatic hypotension. Increases risk of falls. Consider the numerous potential interactions. Reduces the effectiveness of drugs for Alzheimer’s disease. (updated 12.2.2024)