Adport
Adport is a medicine that helps your body accept a transplanted organ by lowering your immune system's activity.
Form
kapseli, kova
Strength
0.75 mg
Active Ingredient
Tacrolimus monohydrate
Manufacturer
Sandoz A/S
How to Use
Dosage
Your doctor will decide your dose based on your weight and condition, and may change it as needed.
Method
Take the capsules by mouth twice daily, usually in the morning and evening. They should be taken on an empty stomach, at least one hour before a meal or 2–3 hours after a meal. Swallow the capsules whole with water.
Important
Your doctor will set and adjust your daily dose based on your condition and blood tests. Never take more than your doctor prescribes.
Possible Side Effects
COMMON
- •High blood sugar levels, sometimes leading to diabetes.
- •High levels of potassium in the blood.
- •Difficulty sleeping.
- •Shaking (tremors) and headaches.
- •High blood pressure.
- •Abnormal liver function tests or problems with the liver.
- •Diarrhea, feeling sick (nausea), throwing up (vomiting), stomach pain, constipation, gas, swelling, or indigestion.
- •Kidney problems, including reduced or painful urination.
- •Severe stomach rupture (gastrointestinal perforation) with intense pain, chills, fever, nausea, or vomiting.
- •The transplanted organ not working as well as it should.
- •Blurred vision.
- •Low numbers of blood cells (platelets, red or white cells), or changes in blood test results.
- •Low magnesium, phosphate, potassium, calcium or sodium in the blood, fluid retention, high uric acid or fats in the blood, or other salt changes.
- •Anxiety, confusion, feeling disoriented, depression, mood changes, nightmares, hallucinations, or other mental health issues.
- •Seizures, problems with consciousness, tingling or numbness in hands and feet, dizziness, writing difficulties, or other nerve problems.
- •Increased sensitivity to light or other eye problems.
- •Ringing in the ears (tinnitus).
- •Reduced blood flow in heart vessels, fast heart rate, bleeding, blocked blood vessels, or low blood pressure.
- •Shortness of breath, changes in lung tissue, fluid around the lungs, sore throat, cough, or flu-like symptoms.
- •Skin problems like itching, rash, hair loss, acne, or increased sweating.
- •Pain in joints, limbs, back, feet, or muscle spasms.
- •General weakness, fever, fluid buildup, pain, discomfort, increased enzyme levels (alkaline phosphatase) in the blood, weight gain, or feeling that your body temperature is off.
RARE
- •Damage to small blood vessels (thrombotic microangiopathy), which can include hemolytic uremic syndrome (HUS) or thrombotic thrombocytopenic purpura (TTP). Symptoms include low or no urine, severe tiredness, yellow skin/eyes, unusual bruising/bleeding, fever, confusion, vision loss, or seizures.
- •Changes in how blood clots or a decrease in all types of blood cells.
- •Dehydration.
- •Low protein or sugar levels in the blood, or high phosphate levels in the blood.
- •Deep unconsciousness (coma), brain bleeding, stroke, paralysis, brain disease, speech or memory problems.
- •Clouding of the eye lens (cataracts).
- •Worsening or complete loss of hearing (deafness).
- •Irregular heartbeat, cardiac arrest, heart failure, heart muscle disease, enlarged heart muscle, very fast heartbeat, or abnormal heart activity on ECG.
- •Blood clot in a limb vein or shock.
- •Severe breathing difficulties, lung disease, or asthma.
- •Bowel obstruction, high amylase levels in the blood, heartburn (reflux), or delayed stomach emptying.
- •Skin inflammation or burning sensation on skin in sunlight.
- •Joint problems, painful or irregular periods.
- •Multiple organ problems, flu-like symptoms, increased sensitivity to heat and cold, chest pressure, nervousness, unusual feelings, high lactate dehydrogenase levels in the blood, or weight loss.
- •Small bleeds under the skin caused by blood clots.
- •Increased muscle stiffness.
- •Deafness.
- •Fluid buildup around the heart.
- •Sudden severe shortness of breath.
- •Cysts in the pancreas.
- •Problems with blood flow in the liver.
- •Increased hair growth.
- •Thirst, falls, chest pressure, reduced movement, or ulcers.
- •Severe skin reactions like Toxic Epidermal Necrolysis (TEN) or Stevens-Johnson Syndrome (SJS), causing widespread blistering, peeling skin, and severe pain. This needs immediate medical help.
- •A serious, unusual heart rhythm called Torsades de pointes, with fast heartbeat, chest pain, fainting, dizziness, nausea, palpitations, and breathing difficulties.
- •Muscle weakness.
- •Abnormal results on a heart ultrasound (echocardiography).
- •Liver failure or narrowing of the bile ducts.
- •Painful urination with blood in the urine.
- •Increased fatty tissue.
- •Serious infections (bacterial, fungal, viral, parasitic) like long-lasting diarrhea, fever, or sore throat, because the medicine weakens your immune system.
- •Benign or malignant tumors (e.g., skin cancer, Kaposi's sarcoma), appearing as new or changed skin spots, ulcers, or lumps.
- •Severe reduction in red blood cells (pure red cell aplasia), hemolytic anemia (low red blood cells due to abnormal breakdown, with tiredness), or febrile neutropenia (low white blood cells that fight infection, with fever). Symptoms can include tiredness, paleness, shortness of breath, dizziness, headache, chest pain, or cold hands and feet.
- •A severe drop in white blood cells (agranulocytosis) with mouth sores, fever, or infection. You might have sudden fever, stiffness, or sore throat.
- •Sudden severe allergic reactions with itchy rash (hives), swelling of hands, feet, ankles, face, lips, mouth or throat (which can make it hard to swallow or breathe), and fainting.
- •Posterior Reversible Encephalopathy Syndrome (PRES) with headache, confusion, mood changes, seizures, or vision problems. Also optic neuropathy (optic nerve disorder) with blurred vision, changes in color vision, or trouble seeing clearly.
Important Warnings
- Do not use Adport if you are allergic to tacrolimus or any other ingredient in this medicine.
- Do not use Adport if you are allergic to any macrolide antibiotics (like erythromycin or clarithromycin).
- Avoid herbal remedies like St. John's wort, as they can affect how Adport works.
- Tell your doctor if you have liver problems, as this may affect your dose.
- Contact your doctor immediately if you have severe stomach pain, chills, fever, nausea, or vomiting, or if you have diarrhea for more than one day.
Show 9 more warnings
- Tell your doctor if you have changes in your heart's electrical activity (prolonged QT interval).
- Limit sun and UV light exposure; use protective clothing and high SPF sunscreen, as there's a risk of skin changes.
- Tell your doctor before getting any vaccinations.
- This medicine can increase your risk of certain disorders, like lymphoproliferative disorders or damage to small blood vessels. Tell your doctor if you have symptoms like fever, bruising, tiredness, confusion, yellow skin or eyes, less urination, vision loss, or seizures.
- Do not stop taking Adport without your doctor's approval, as this increases the risk of organ rejection.
- Do not drive or use machines if you feel dizzy, sleepy, or have blurred vision after taking Adport.
- Do not breastfeed while taking Adport.
- Avoid grapefruit and grapefruit juice while on Adport.
- Do not take Adport with ciclosporin.