Adport
Adport is a medicine that helps your body accept a transplanted organ by calming your immune system.
Form
kapseli, kova
Strength
5 mg
Active Ingredient
Tacrolimus monohydrate
Manufacturer
Sandoz A/S
How to Use
Dosage
Your doctor will decide your exact dose based on your weight and health; the usual starting dose after an organ transplant is 0.075–0.30 mg per kg per day.
Method
Take this medicine by mouth twice a day, usually in the morning and evening, on an empty stomach (at least 1 hour before or 2-3 hours after a meal). Swallow the capsules whole with a glass of water, immediately after removing them from the blister pack.
Important
Your doctor will set and adjust your maximum daily dose.
Possible Side Effects
COMMON
- •High blood sugar, diabetes, high potassium levels in blood
- •Sleep problems
- •Tremors, headache
- •High blood pressure
- •Abnormal liver function tests
- •Diarrhea, nausea, stomach pain, indigestion, constipation, gas, bloating, loose stools, stomach discomfort, stomach bleeding, mouth inflammation or ulcers, fluid buildup in abdomen
- •Kidney problems, less urine, weak or painful urination
- •Changes in blood counts (low platelets, red or white cells; high white cells)
- •Low blood levels of magnesium, phosphate, potassium, calcium, or sodium; fluid retention; high uric acid or fat in blood; poor appetite; high blood acidity; other salt imbalances
- •Anxiety, confusion, feeling lost or disoriented, depression, mood changes, nightmares, hallucinations, mental problems
- •Seizures, problems with consciousness, tingling or numbness in hands and feet (sometimes painful), dizziness, trouble writing, nerve problems
- •Increased sensitivity to light, eye problems, blurred vision, ringing in the ears (tinnitus)
- •Less blood flow in heart vessels, fast heart rate, bleeding, partial or complete blood vessel blockage, low blood pressure
- •Shortness of breath, changes in lung tissue, fluid around lungs, sore throat, cough, flu-like symptoms
- •Liver enzyme and function problems, yellow skin due to liver issues, liver tissue damage and inflammation
- •Itching, rash, hair loss, acne, increased sweating
- •Joint, limb, back, and foot pain, muscle spasms
- •General weakness, fever, fluid retention, pain and discomfort, increased alkaline phosphatase enzyme in blood, weight gain, abnormal body temperature sensation
- •Severe stomach pain and problems with your transplanted organ
RARE
- •Problems with blood clotting, low count of all blood cells
- •Dehydration, low blood protein or sugar, high blood phosphate
- •Deep unconsciousness (coma), brain bleed, stroke, paralysis, brain disorders, speech or language problems, memory problems
- •Cloudy eye lens, hearing loss
- •Irregular heartbeat, cardiac arrest, heart failure, heart muscle disease, enlarged heart muscle, faster heartbeat, abnormal ECG, changes in heart rate, blood clot in a leg or arm vein, shock
- •Breathing problems, lung disease, asthma, acute shortness of breath
- •Bowel blockage, increased blood amylase (an enzyme), stomach contents reflux into esophagus, slow stomach emptying
- •Skin inflammation, burning sensation on skin in sunlight
- •Joint problems, increased muscle stiffness, muscle weakness
- •No urine production, painful periods, menstrual problems
- •Multiple organ failure, flu-like symptoms, increased sensitivity to heat and cold, chest pressure, nervousness or unusual feeling, increased LDH enzyme in blood, weight loss
- •Small blood vessel damage (thrombotic microangiopathy) including hemolytic uremic syndrome: little or no urine, extreme tiredness, yellow skin/eyes, unusual bruising or bleeding, signs of infection
- •Blood clotting disorder (thrombotic thrombocytopenic purpura) with fever, skin bruising (red pinpricks), tiredness, confusion, yellow skin/eyes, little or no urine, vision loss, and seizures
- •Severe skin reaction (toxic epidermal necrolysis or Stevens-Johnson syndrome) with skin and mucous membrane damage, blisters, red swollen skin that peels off, widespread skin pain, facial swelling, severe skin blistering in mouth, eyes, genitals, hives, swollen tongue, red/purple rash
- •Blindness
- •Cyst formation in the pancreas, liver circulation disorders, liver failure, bile duct narrowing
- •Increased hair growth
- •Thirst, falls, chest tightness, decreased mobility, ulcers
- •Painful urination with blood in urine
- •Increased fat tissue
Important Warnings
- Do not use Adport if you are allergic to tacrolimus or macrolide antibiotics (like erythromycin, clarithromycin, or josamycin).
- Avoid St. John's Wort, other herbal remedies, grapefruit, and grapefruit juice, as they can affect how Adport works.
- Tell your doctor if you have liver problems, severe stomach pain, diarrhea lasting over a day, changes in heart rhythm (QT prolongation), or signs of small blood vessel damage (like fever, bruising, tiredness, confusion, yellow skin/eyes, less urination, blurry vision, or seizures).
- Protect your skin from sun and UV light with clothing and sunscreen, as Adport can increase the risk of skin cancer.
- Inform your doctor before any vaccinations. Always tell any other doctor you see that you are taking tacrolimus.
Show 5 more warnings
- Avoid breathing in Adport powder or getting it on your skin or eyes. If contact occurs, rinse thoroughly.
- Do not breastfeed while using Adport. Talk to your doctor if you are pregnant or planning to be.
- Do not drive or operate machines if you feel dizzy, sleepy, or have blurred vision after taking Adport.
- If you have a sugar intolerance, talk to your doctor before taking Adport, as it contains lactose.
- Taking Adport with sirolimus or everolimus can increase the risk of developing certain blood disorders.