Adport
Adport is a medicine that helps your body accept a new organ after a transplant by calming your immune system.
Form
kapseli, kova
Strength
0.5 mg
Active Ingredient
Tacrolimus monohydrate
Manufacturer
Sandoz A/S
How to Use
Dosage
Your doctor will decide your specific dose based on your weight and the organ transplanted, usually 0.075-0.30 mg per kg per day initially.
Method
Take Adport capsules whole with water, twice a day (usually morning and evening). Take them on an empty stomach, at least 1 hour before or 2-3 hours after a meal. Do not crush or chew. Avoid grapefruit and grapefruit juice.
Important
Your doctor will determine your maximum daily dose and will adjust it as your condition stabilizes.
Possible Side Effects
COMMON
- •High blood sugar, or diabetes.
- •High potassium levels in the blood.
- •Trouble sleeping.
- •Headaches, shaking.
- •High blood pressure.
- •Changes in liver test results.
- •Diarrhea, feeling sick (nausea).
- •Kidney problems.
- •Changes in blood cell counts (red, white blood cells, platelets).
- •Imbalance of salts (like magnesium, phosphate, potassium, calcium, sodium) in your blood, fluid buildup.
- •Anxiety, confusion, depression, mood changes, nightmares, hallucinations.
- •Seizures, altered awareness, tingling or numbness in hands/feet, dizziness, problems with writing, nerve issues.
- •Increased sensitivity to light, other eye problems, ringing in the ears.
- •Reduced blood flow to the heart, fast heart rate, bleeding, blocked blood vessels, low blood pressure.
- •Shortness of breath, lung changes, fluid around lungs, sore throat, cough, flu-like symptoms.
- •Stomach pain, infections or ulcers in the stomach/intestines, stomach bleeding, mouth sores, fluid in the abdomen, vomiting, indigestion, constipation, gas, bloating, loose stools.
- •Yellow skin due to liver problems, liver tissue damage or inflammation.
- •Itching, rash, hair loss, acne, increased sweating.
- •Pain in joints, limbs, back, feet, muscle spasms.
- •Kidney failure, reduced or painful urination.
- •General weakness, fever, fluid retention in the body, pain, discomfort, weight gain, feeling abnormal body temperature.
RARE
- •Severe stomach pain, possibly with chills, fever, nausea, vomiting, or a tear in the digestive tract.
- •Your transplanted organ not working as it should.
- •Blurred vision or blindness, changes in color vision, difficulty seeing details or narrowed field of vision.
- •Serious problems with small blood vessels and kidneys (symptoms like fever, bruises, extreme tiredness, confusion, yellow skin/eyes, very little urine, vision loss, seizures).
- •Severe skin reactions such as painful, widespread rashes, blisters, peeling skin, facial swelling, or swollen tongue.
- •Dangerous changes in heart rhythm, chest pain, fainting, dizziness, nausea, rapid heartbeat, and breathing difficulties.
- •Severe infections caused by bacteria, fungi, viruses, or parasites, which can lead to prolonged diarrhea, fever, and sore throat.
- •Development of benign or cancerous tumors, including skin cancer or a rare cancer called Kaposi's sarcoma (look for new or changing skin spots, sores, or lumps).
- •Severe decrease in red or white blood cells, leading to tiredness, pale skin, shortness of breath, dizziness, headache, chest pain, cold hands/feet, or fever.
- •Sudden, itchy rash (hives), swelling of hands, feet, ankles, face, lips, mouth, or throat (making it hard to swallow or breathe), feeling faint.
- •Headache, confusion, mood changes, seizures, and vision disturbances, which can be signs of a brain condition called Posterior Reversible Encephalopathy Syndrome (PRES).
- •Dehydration.
- •Low blood protein or sugar, high blood phosphate.
- •Coma, bleeding in the brain, stroke, paralysis, or other brain diseases with speech, language, or memory problems.
- •Impaired hearing or deafness.
- •Blood clot in a vein in your leg or arm, shock.
- •Severe breathing difficulties, lung diseases, asthma.
- •Bowel blockage, increased levels of a blood enzyme called amylase, acid reflux, delayed stomach emptying.
- •Skin inflammation with a burning sensation when exposed to the sun.
- •Joint diseases.
- •Inability to urinate, painful or abnormal menstrual bleeding.
- •Muscle weakness or increased muscle stiffness.
- •Liver failure or narrowing of the bile ducts.
- •Painful urination with blood in the urine.
- •Increased fat tissue.
- •Increased thirst, falls.
Important Warnings
- Do not use Adport if you are allergic to tacrolimus, any other ingredient in this medicine, or to macrolide antibiotics (like erythromycin or clarithromycin).
- You will need regular doctor visits and tests (blood, urine, heart, eye, neurological) while taking Adport to ensure the right dose and monitor your health.
- Avoid herbal remedies, especially St. John's wort, as they can affect how Adport works. Always ask your doctor before taking any other remedies.
- Tell your doctor if you have liver problems, as this may affect your Adport dose.
- If you experience severe stomach pain with chills, fever, nausea, vomiting, or diarrhea lasting more than a day, tell your doctor immediately.
Show 12 more warnings
- Limit sun and UV exposure; wear protective clothing and high-SPF sunscreen, as this medicine can increase the risk of skin cancer.
- Inform your doctor if you need any vaccinations.
- Tell your doctor if you experience fever, bruises, extreme tiredness, confusion, yellow skin/eyes, reduced urination, vision loss, or seizures, as these could be signs of serious blood vessel problems.
- The risk of blood vessel problems may increase if Adport is taken with sirolimus or everolimus.
- Avoid inhaling or direct contact of the capsule contents with your skin or eyes. Rinse immediately if contact occurs.
- Do not take Adport with ciclosporin.
- Always tell any other doctor treating you that you are taking tacrolimus.
- Do not breastfeed while on Adport treatment. Consult your doctor if you are pregnant or planning to become pregnant.
- Do not drive or operate machinery if you feel dizzy, drowsy, or have blurred vision after taking Adport, especially with alcohol.
- Do not swallow the desiccant (drying agent) found in the foil pouch.
- Do not take a double dose to make up for a forgotten one.
- Do not stop taking Adport without your doctor's advice, as this increases the risk of your body rejecting the transplanted organ.