Aderolio
Aderolio is a medicine that helps your body prevent the rejection of transplanted organs like kidneys, hearts, or livers.
Form
tabletti
Strength
0.25 mg
Active Ingredient
Everolimus
Manufacturer
Sandoz A/S
How to Use
Dosage
The usual starting dose is 1.5 mg per day for kidney and heart transplants, and 2.0 mg per day for liver transplants, split into a morning and evening dose.
Method
Take the tablets whole with a glass of water. Do not crush them.
Important
Your doctor will decide the maximum daily dose for your individual needs.
Possible Side Effects
COMMON
- •Infections (viral, bacterial, and fungal)
- •Lower respiratory tract infections, such as pneumonia
- •Upper respiratory tract infections, such as sore throat and common cold
- •Urinary tract infections
- •Anemia (lack of red blood cells)
- •Low white blood cell count (increased infection risk) and low platelet count (bleeding or bruising)
- •High blood fat levels (cholesterol and triglycerides)
- •New diabetes (high blood sugar)
- •Low potassium levels in blood
- •Anxiety
- •Difficulty sleeping (insomnia)
- •Headache
- •Fluid buildup around the heart, which can make it harder for the heart to pump blood
- •High blood pressure
- •Blood clots in veins
- •Fluid buildup in the lungs or chest cavity, which can cause shortness of breath
- •Cough
- •Shortness of breath
- •Diarrhea
- •Nausea
- •Vomiting
- •Abdominal pain
- •General pain
- •Fever
- •Fluid retention in tissues
- •Abnormal wound healing
RARE
- •Blood poisoning
- •Wound infections
- •Cancer and benign tumors
- •Skin cancer
- •Kidney disorder with low platelets and red blood cells, with or without rash
- •Red blood cell breakdown
- •Low red blood cell and platelet count
- •Fast heart rate
- •Nosebleeds
- •Low blood cell count (weakness, bruising, frequent infections)
- •Blood clots in kidney blood vessels (can lead to transplant loss)
- •Bleeding disorders
- •Lymph fluid cysts
- •Mouth or throat pain
- •Pancreatitis
- •Mouth ulcers
- •Acne
- •Hives and other allergic reactions, such as swelling of the face or throat
- •Rash
- •Joint pain
- •Muscle pain
- •Protein in urine
- •Kidney disorders
- •Impotence
- •Surgical wound hernia
- •Abnormal liver function tests
- •Menstrual problems (including absent or heavy periods)
- •Lymphoma (lymphatic tissue cancer)
- •Low testosterone levels
- •Lung inflammation
- •Liver inflammation
- •Jaundice
- •Ovarian cysts
- •Abnormal protein buildup in lungs (dry cough, fatigue, shortness of breath)
- •Blood vessel inflammation
- •Severe rash with swelling
- •Swelling, feeling of heaviness or tightness, pain, limited movement (lymphedema)
- •Low iron levels in blood
Important Warnings
- Aderolio weakens your immune system, which can increase your risk of infections. If you get a fever or other signs of infection, contact your doctor immediately.
- If you experience confusion, speech problems, memory loss, headache, vision problems, or seizures, seek immediate medical attention as these could be signs of a serious brain condition.
- Aderolio can make wound healing more difficult if you've recently had surgery or have wounds.
- Aderolio can increase your risk of cancer, especially skin and lymph node cancers. Protect your skin from the sun and avoid UV light.
- Your doctor will regularly check your kidney function, blood fat and sugar levels, and protein in your urine.
Show 7 more warnings
- If you have liver problems or a history of liver disease, tell your doctor, as your dose may need to be adjusted.
- If you have a cough, shortness of breath, or wheezing, tell your doctor.
- Aderolio may reduce male fertility, but this effect is usually reversible after treatment stops.
- Do not use Aderolio if you are allergic to everolimus, sirolimus, or any other ingredient in this medicine.
- Do not use Aderolio if you are pregnant unless your doctor considers it absolutely necessary. If you can become pregnant, use effective contraception during treatment and for 8 weeks after. Do not breastfeed while taking Aderolio.
- Do not drink grapefruit juice or eat grapefruit with Aderolio, as they can affect how the medicine works.
- Aderolio contains lactose. If you have a sugar intolerance, talk to your doctor before taking this medicine.