Abbonate
Abbonate is an antidepressant containing tranylcypromine, used to treat severe depression in adults when other treatments have not been effective.
Form
tabletti, kalvopäällysteinen
Strength
20 mg
Active Ingredient
Tranylcypromine sulphate
Manufacturer
Abboxia AB
How to Use
Dosage
The starting dose is half a tablet (10 mg) once daily in the morning. The recommended daily dose is 1–2 tablets.
Method
Swallow tablets with a glass of water. The tablets can be divided into two equal halves by pressing down on the middle of the tablet on a hard surface.
Important
The maximum daily dose is 3 Abbonate tablets (up to 60 mg/day).
Possible Side Effects
COMMON
- •Insomnia, sleep disturbances
- •Low blood pressure, low blood pressure upon standing
- •Anxiety, agitation, restlessness
- •Dizziness, dry mouth, fatigue
- •Palpitations
- •Weight gain, weight loss, weakness
RARE
- •Sudden increase in blood pressure (hypertensive crisis) with fast heartbeat, facial and neck redness, headache, stiff neck, nausea, vomiting, sensitivity to light
- •Bleeding in the brain
- •Anemia, decreased number of blood cells
- •Psychological dependence
- •Seizures
- •Swelling due to fluid retention (edema)
- •Constipation, diarrhea
- •Sweating
- •Muscle cramps, muscle pain
- •Orgasm, erection, and ejaculation disorders
- •Hallucinations, confusion
- •Nerve pain (polyneuropathy)
- •Blurred vision
- •Abnormal liver function, increased liver enzyme activity
- •Hair loss
- •Allergic skin reactions
- •Joint pain
- •Decreased urine production
- •High body temperature
- •Suicidal thoughts, self-harming behavior
- •Drowsiness, tremors
- •Tinnitus
- •Nausea, vomiting, gastrointestinal symptoms
- •Difficulty urinating
- •Chest pain
- •Feeling cold
- •Exhaustion
Important Warnings
- If you are allergic to tranylcypromine or any other ingredient in this medicine.
- If you have an adrenal gland tumor (pheochromocytoma) or gastrointestinal cancer (carcinoid tumors).
- If you have or recently had heart or blood vessel problems, such as a recent stroke.
- If you have severe, uncontrolled high blood pressure.
- If you have liver or kidney failure or disease.
Show 5 more warnings
- If you have thoughts of harming yourself or suicide – contact your doctor immediately.
- If you experience symptoms of serotonin syndrome, such as aggression, hallucinations, coma, fast heartbeat, or diarrhea – seek immediate medical attention.
- Avoid tyramine-rich foods and drinks (e.g., aged cheeses, processed meats, alcohol) during treatment and for 14 days after, as they can cause dangerously high blood pressure.
- This medicine should not be used by children and adolescents under 18 years of age.
- Do not use during pregnancy or breastfeeding.